2,8,12,18-四乙基-3,7,13,17-四甲基-21H,23H-卟啉合成路线 （共 36 条）
反应条件
toluene-4-sulfonic acid in methanol; dichloromethane
16 h;
参考文献
Wijesekera, Tilak P.; Paine, John B.; Dolphin, David
Journal of Organic Chemistry, 1985 , vol. 50, # 20 p. 3832 - 3838
反应条件
1: With trifluoroacetic acid in dichloromethane
T=20°C; MacDonald-type condensation;
2: With chloranil in dichloromethane
Further stages.;
参考文献
Juillard, Sandrine; Simonneaux, Gerard
Synlett, 2006 , # 17 p. 2818 - 2820
反应条件
1: 59 percent / 48percent HBr / 8 h / Heating
2: 10 g / Br2 / acetic acid / 0.5 h / 80 °C
3: 3.2 g / 0.5 h / Heating
4: 2.) tetrachloro-o-benzoquinone / 1.) benzene, reflux, 1 h, 2.) room temp., 30 min
View Scheme
参考文献
Chang, C. K.; Abdalmuhdi, Ismail
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5388 - 5390
反应条件
formic acid
und Luft;
参考文献
Fischer; Halbig
Justus Liebigs Annalen der Chemie, 1926 , vol. 450, p. 151,154,160
反应条件
potassium phosphate buffer; potassium hexacyanoferrate(III) in methanol; dichloromethane
1.) reflux, 2 h, 2.) reflux, 4 h;
参考文献
Schell, Christian; Hombrecher, Hermann K.
Chemistry - A European Journal, 1999 , vol. 5, # 2 p. 587 - 598
反应条件
1.1: 52 percent / POCl3 / CH2Cl2
2.1: trifluoroacetic acid / CH2Cl2 / 20 °C
2.2: 40 percent / p-chloranyl / CH2Cl2
View Scheme
参考文献
Juillard, Sandrine; Simonneaux, Gerard
Synlett, 2006 , # 17 p. 2818 - 2820
反应条件
1.1: 89 percent / NaOH
2.1: trifluoroacetic acid / CH2Cl2 / 20 °C
2.2: 40 percent / p-chloranyl / CH2Cl2
View Scheme
参考文献
Juillard, Sandrine; Simonneaux, Gerard
Synlett, 2006 , # 17 p. 2818 - 2820
反应条件
1: NaOH / ethanol / 8 h / Heating
2: ethanolamine / Heating
3: 2.) tetrachloro-o-benzoquinone / 1.) benzene, reflux, 1 h
View Scheme
参考文献
Chang, C. K.; Abdalmuhdi, Ismail
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5388 - 5390
反应条件
1: 10 g / Br2 / acetic acid / 0.5 h / 80 °C
2: 3.2 g / 0.5 h / Heating
3: 2.) tetrachloro-o-benzoquinone / 1.) benzene, reflux, 1 h, 2.) room temp., 30 min
View Scheme
参考文献
Chang, C. K.; Abdalmuhdi, Ismail
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5388 - 5390
反应条件
1.1: 100 percent / NaOH / ethane-1,2-diol / 1 h / Heating
2.1: 75 percent / PhCOCl / 0 - 20 °C
3.1: 162 mg / HBr; AcOH / methanol / 0.5 h / 20 °C
4.1: CuCl2 / dimethylformamide / 4 h / 20 °C
4.2: 31 percent / H2SO4; CF3CO2H / 0.75 h / 20 °C
View Scheme
参考文献
Lash, Timothy D.; Chen, Shaohua
Tetrahedron, 2005 , vol. 61, # 49 p. 11577 - 11600
