4-氟-2-硝基乙酰苯胺合成路线 （共 23 条）
反应条件
MOA; water; nitric acid in chloroform Nitration; 6 h; Heating;
参考文献
Sana, Sariah; Rajanna; Ali, Mir Moazzam; Saiprakash
Chemistry Letters, 2000 , # 1 p. 48 - 49
反应条件
1: 2 h / 110 °C 2: nitric acid / 0 - 5 °C View Scheme
参考文献
Chopra, Sidharth; Koolpe, Gary A.; Tambo-Ong, Arlyn A.; Matsuyama, Karen N.; Ryan, Kenneth J.; Tran, Tran B.; Doppalapudi, Rupa S.; Riccio, Edward S.; Iyer, Lalitha V.; Green, Carol E.; Wan, Baojie; Franzblau, Scott G.; Madrid, Peter B.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 13 p. 6047 - 6060
反应条件
acetic anhydride T=0°C;
参考文献
Swarts
Recueil des Travaux Chimiques des Pays-Bas, 1916 , vol. 35, p. 142
Chem. Zentralbl., 1913 , vol. 84, # II p. 760
反应条件
1: concentrated H2SO4; benzene; NaN3 2: acetic acid; Cu(NO3)2 View Scheme
参考文献
Takatori et al.
Yakugaku Zasshi, 1958 , vol. 78, p. 108
Chem.Abstr., 1958 , p. 11013
参考文献
Wilkinson; Finar
Journal of the Chemical Society, 1948 , p. 288,290
反应条件
copper(II) nitrate; acetic acid
参考文献
Takatori et al.
Yakugaku Zasshi, 1958 , vol. 78, p. 108
Chem.Abstr., 1958 , p. 11013
参考文献
Swarts
Recueil des Travaux Chimiques des Pays-Bas, 1916 , vol. 35, p. 142
Chem. Zentralbl., 1913 , vol. 84, # II p. 760
反应条件
1: 90 percent / sodium ethoxide / ethanol / 4 h / Heating 2: 1.) aq.hydrochloric acid, NaNO2, 2.) CuCN / 1.) 0-3 deg C, 1 hr., 2.) 80-90 deg C 3: 73 percent / aq.H2SO4 (70 percent) / 6 h / 90 - 110 °C View Scheme
参考文献
Protiva, Miroslav; Jilek, Jiri; Rajsner, Miroslav; Pomykacek, Josef; Ryska, Miroslav; et al.
Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 3 p. 698 - 722
反应条件
1: 90 percent / sodium ethoxide / ethanol / 4 h / Heating 2: 1.) aq.hydrochloric acid, NaNO2, 2.) CuCN / 1.) 0-3 deg C, 1 hr., 2.) 80-90 deg C 3: 76 percent / 1.) aq.H2SO4, acetic acid, 2.) acetic acid, acetic anhydride / 8 h / 1.) reflux, 8 hrs., 2.) ferlux 15 min., View Scheme
参考文献
Protiva, Miroslav; Jilek, Jiri; Rajsner, Miroslav; Pomykacek, Josef; Ryska, Miroslav; et al.
Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 3 p. 698 - 722
反应条件
sodium ethanolate in ethanol 4 h; Heating;
参考文献
Protiva, Miroslav; Jilek, Jiri; Rajsner, Miroslav; Pomykacek, Josef; Ryska, Miroslav; et al.
Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 3 p. 698 - 722
