1-苯基-4-(1-哌啶基)丁烷-1-酮合成路线 （共 6 条）
反应条件
potassium iodide in ethylene glycol; toluene
T=100°C; 12 h;
参考文献
Huang; Hall
European Journal of Medicinal Chemistry, 1996 , vol. 31, # 4 p. 281 - 290
反应条件
cyclohexanone; Al tri-t-BuO-; toluene
参考文献
Lutz et al.
Journal of the American Chemical Society, 1950 , vol. 72, p. 4085,4089
反应条件
1: p-toluenesulfonic acid / benzene / Heating
2: 1.) NaI, 2.) aq. HCl / 1.) reflux, 48 h, 2.) from 80 deg C to RT, 16 h
View Scheme
参考文献
Hoefle, M. L.; Blouin, L. T.; Fleming, R. W.; Hastings, S.; Hinkley, J. M.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 12 - 19
反应条件
1: diethyl ether
2: cyclohexanone; aluminium tert-butylate; toluene
View Scheme
参考文献
Lutz et al.
Journal of the American Chemical Society, 1950 , vol. 72, p. 4085,4089
反应条件
hydrogenchloride; sodium iodide
1.) reflux, 48 h, 2.) from 80 deg C to RT, 16 h; Yield given. Multistep reaction;
参考文献
Hoefle, M. L.; Blouin, L. T.; Fleming, R. W.; Hastings, S.; Hinkley, J. M.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 12 - 19
反应条件
in diethyl ether
Ambient temperature;
参考文献
Sakuraba; Achiwa
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 5 p. 748 - 753
