2-氨基-4-氯-6-甲基嘧啶合成路线 （共 21 条）
反应条件
N-chloro-succinimide; triphenylphosphine in 1,4-dioxane Chlorination; substitution; 4 h; Heating;
参考文献
Sugimoto, Osamu; Mori, Miho; Moriya, Keisuke; Tanji, Ken-Ichi
Helvetica Chimica Acta, 2001 , vol. 84, # 5 p. 1112 - 1118
反应条件
1: methylmagnesium bromide With zinc dibromide in tetrahydrofuran; diethyl ether T=-60°C; 1 h; 2: 2-methyl-4,6-dichloro-pyrimidine With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; diethyl ether T=60°C; 8 h;
参考文献
TAISHO PHARMACEUTICAL CO., LTD.; Arena Pharmaceuticals, Inc
Patent: WO2005/95357 A2, 2005 ;
Location in patent: Page/Page column 167; 168 ;
WO 2005/095357 A2
反应条件
T=550°C; Yield given. Further byproducts given. Yields of byproduct given;
参考文献
Busby, Reginald E.; Khan, Mohammad A.; Khan, Mohammad R.; Parrick, John; Shaw, C. J. Granville; Iqbal, Mohammad
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1427 - 1430
反应条件
T=550°C; Yield given. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Busby, Reginald E.; Khan, Mohammad A.; Khan, Mohammad R.; Parrick, John; Shaw, C. J. Granville
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1431 - 1435
反应条件
T=550°C; Yield given. Further byproducts given. Yields of byproduct given;
参考文献
Busby, Reginald E.; Khan, Mohammad A.; Khan, Mohammad R.; Parrick, John; Shaw, C. J. Granville
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1431 - 1435
反应条件
T=550°C; Yield given. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Busby, Reginald E.; Khan, Mohammad A.; Khan, Mohammad R.; Parrick, John; Shaw, C. J. Granville
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1431 - 1435
反应条件
T=550°C; Yield given. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Busby, Reginald E.; Khan, Mohammad A.; Khan, Mohammad R.; Parrick, John; Shaw, C. J. Granville; Iqbal, Mohammad
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1427 - 1430
参考文献
Schmidt
Chemische Berichte, 1902 , vol. 35, p. 1577
反应条件
potassium carbonate T=200 - 220°C;
参考文献
Matsukawa et al.
Yakugaku Zasshi, 1950 , vol. 70, p. 283,284
Chem.Abstr., 1951 , p. 2894
反应条件
ethanol; ammonia T=150°C;
参考文献
Schmidt
Chemische Berichte, 1902 , vol. 35, p. 1577
