3a-乙酰氧基-12-氧代-5b-胆-9(11)-烯-24-酸甲酯合成路线 （共 5 条）
反应条件
1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 16 h / 2585.81 Torr 2: sodium hydroxide; methanol / 2 h / 20 °C 3: thionyl chloride / 1 h / 0 - 20 °C 4: pyridinium chlorochromate / dichloromethane / 20 °C 5: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 20 °C / Inert atmosphere View Scheme
参考文献
KYTHERA BIOPHARMACEUTICALS, INC.; MORIARTY, Robert, M.; DAVID, Nathaniel, E.; MAHMOOD, Nadir, Ahmeduddin
Patent: WO2012/21133 A1, 2012 ;
反应条件
1.1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 16 h / 45 - 50 °C / 2585.81 Torr 2.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 5 h / 0 - 10 °C 2.2: 0 - 5 °C 3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 4 h / 25 - 35 °C 3.2: pH 1 - 2 View Scheme
参考文献
Kythera Biopharmaceuticals, Inc.; Moriarty, Robert M.; David, Nathaniel E.; Mahmood, Nadir Ahmeduddin
Patent: US2013/252931 A1, 2013 ;
反应条件
lithium aluminium tetrahydride; aluminium trichloride
参考文献
Ziegler,P.; Grivas,J.C.
Canadian Journal of Chemistry, 1968 , vol. 46, p. 1574 - 1577
反应条件
hydrogenchloride; methanol
参考文献
Seebeck; Reichstein
Helvetica Chimica Acta, 1943 , vol. 26, p. 536,560
反应条件
1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 16 h / 2585.81 Torr
2: sodium hydroxide; methanol / 2 h / 20 °C
View Scheme
参考文献
KYTHERA BIOPHARMACEUTICALS, INC.; MORIARTY, Robert, M.; DAVID, Nathaniel, E.; MAHMOOD, Nadir, Ahmeduddin
Patent: WO2012/21133 A1, 2012 ;
