2-(4-甲基苯基)吡啶合成路线 （共 103 条）
反应条件
N-heterocyclic carbene-based nickel(II) complex in tetrahydrofuran T=20°C; Kumada reaction; 12 h;
参考文献
Liu, Ning; Wang, Zhong-Xia
Journal of Organic Chemistry, 2011 , vol. 76, # 24 p. 10031 - 10038
反应条件
ammonium chloride; zinc in tetrahydrofuran T=22 - 38°C; 0.583333 h;
参考文献
Campeau, Louis-Charles; Fagnou, Keith
Organic Syntheses, 2012 , vol. 88, p. 22 - 32
反应条件
potassium fluoride; copper(l) iodide; palladium diacetate; di-(1-adamantyl)-n-butylphosphine in N,N-dimethyl-formamide T=90°C; Hiyama coupling; 12 h; Inert atmosphere;
参考文献
Blakemore, David C.; Marples, Louise A.
Tetrahedron Letters, 2011 , vol. 52, # 32 p. 4192 - 4195
反应条件
hydrogen; triethylamine; palladium on activated carbon T=40°C; P=760.051 Torr; 5 h;
参考文献
US6365745 B1, ;
Table 1 ;
反应条件
NiF2; 1,3-bis(2,6-diisopropylphenyl)imidazolinium chloride in tetrahydrofuran T=60°C; 16 h; Inert atmosphere;
参考文献
Hatakeyama, Takuji; Hashimoto, Sigma; Ishizuka, Kentaro; Nakamura, Masaharu
Journal of the American Chemical Society, 2009 , vol. 131, # 33 p. 11949 - 11963
反应条件
1: para-bromotoluene With lithium 2: With zinc(II) chloride 3: alpha-chloropyridine With nickel phosphine amido pincer complex in tetrahydrofuran; 1-methyl-pyrrolidin-2-one T=70°C; Negishi cross-coupling; 12 h; Further stages.;
参考文献
Wang, Li; Wang, Zhong-Xia
Organic Letters, 2007 , vol. 9, # 21 p. 4335 - 4338
反应条件
pyridine; copper(I) oxide; triphenylphosphine; PdI2 in 1-methyl-pyrrolidin-2-one T=50 - 190°C; 6 h; Microwave irradiationInert atmosphere;
参考文献
Haley, Christopher K.; Gilmore, Christopher D.; Stoltz, Brian M.
Tetrahedron, 2013 , vol. 69, # 27-28 p. 5732 - 5736
反应条件
K3PO4*7H2O; palladium dichloride in ethanol; water T=80°C; Suzuki-Miyaura reaction; 0.166667 h;
参考文献
Liu, Chun; Ni, Qijian; Hu, Pingping; Qiu, Jieshan
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 4 p. 1054 - 1060
反应条件
1: para-bromotoluene With iodine; magnesium in tetrahydrofuran T=35°C; 2 h; 2: 2-bromo-pyridine With tetrakis(triphenylphosphine) palladium(0); zinc(II) chloride in tetrahydrofuran; toluene T=50°C; 2.5 h; Conversion of starting material;
参考文献
Euticals Prime European Therapeutical SpA
Patent: US6765097 B1, 2004 ;
Location in patent: Page column 11-12 ;
反应条件
(IPr)Ni(π-allyl)Cl in tetrahydrofuran T=60°C; Kumada Cross-Coupling; 12 h; Inert atmosphere;
参考文献
Iglesias, Maria Jose; Prieto, Auxiliadora; Nicasio, M. Carmen
Organic Letters, 2012 , vol. 14, # 17 p. 4318 - 4321
