双(苯并[D]噻唑-2-基)甲酮合成路线 （共 10 条）
反应条件
air; triethylamine in dimethyl sulfoxide 12 h; Ambient temperature;
参考文献
Boga, Carla; Forlani, Luciano; Todesco, Paolo E.
Gazzetta Chimica Italiana, 1997 , vol. 127, # 4 p. 197 - 200
反应条件
in dichloromethane T=0°C; 15 h;
参考文献
Jutzi, Peter; Gilge, Ullrich
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1011 - 1014
反应条件
triethylamine in acetonitrile T=20°C; 15 h;
参考文献
Regel,E.
Justus Liebigs Annalen der Chemie, 1977 , p. 159 - 168
反应条件
n-butyllithium 1) THF, -78 deg C, 30 min, 2) THF, -78 deg C, 30 min then -78 deg C to RT, 2 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Nagasaki, Izuru; Suzuki, Yumiko; Iwamoto, Ken-Ichi; Higashino, Takeo; Miyashita, Akira
Heterocycles, 1997 , vol. 46, # 1 p. 443 - 450
反应条件
potassium dichromate; sulfuric acid in acetic acid 2 h; Ambient temperaturevar. temp.:65-75 deg C; var. reag.: CrO3, Mn(OAc)2, Pb(OAc)2*3H2O, Fe(OAc)2, NaOMe in MeOH in air; Product distribution;
参考文献
Bradamante, Silvia; Facchetti, Antonio; Pagani, Giorgio A.
Gazzetta Chimica Italiana, 1996 , vol. 126, # 6 p. 329 - 338
反应条件
1: 4-iodobenzoic acid ethyl ester; iso-propylmagnesium bromide in tetrahydrofuran T=0°C; 0.333333 h; Inert atmosphere; 2: bis(1,3-benzothiazol-2-yl)methanone in tetrahydrofuran T=0°C; 1 h; Inert atmosphere; 3: With (NH4)2SO4 in tetrahydrofuran; water Inert atmosphere; regioselective reaction;
参考文献
Boga, Carla; Micheletti, Gabriele
European Journal of Organic Chemistry, 2010 , # 29 p. 5659 - 5665
反应条件
1: 4-iodobenzoic acid ethyl ester; iso-propylmagnesium bromide in tetrahydrofuran T=0°C; 0.333333 h; Inert atmosphere; 2: bis(1,3-benzothiazol-2-yl)methanone in tetrahydrofuran T=0°C; 1 h; Inert atmosphere; 3: With (NH4)2SO4 in tetrahydrofuran; water Inert atmosphere; regioselective reaction;
参考文献
Boga, Carla; Micheletti, Gabriele
European Journal of Organic Chemistry, 2010 , # 29 p. 5659 - 5665
反应条件
1: in tetrahydrofuran
T=20°C; 1 h; Inert atmosphere;
2: With ammonium chloride in tetrahydrofuran; water
Inert atmosphere; regioselective reaction;
参考文献
Boga, Carla; Micheletti, Gabriele
European Journal of Organic Chemistry, 2010 , # 29 p. 5659 - 5665
反应条件
in diethyl ether; benzene
T=50°C; 36 h;
参考文献
Regel,E.
Justus Liebigs Annalen der Chemie, 1977 , p. 159 - 168
反应条件
in tetrahydrofuran
T=-70°C; 0.25 h;
参考文献
Boga, Carla; Forlani, Luciano; Todesco, Paolo E.
Gazzetta Chimica Italiana, 1997 , vol. 127, # 4 p. 197 - 200
