4-(3-氧代-4-吗啉基)硝基苯合成路线 （共 13 条）
反应条件
in ethanol; ethyl acetate
参考文献
Aventis Pharma Deutschland GmbH
Patent: EP1571154 A1, 2005 ;
反应条件
1.1: hydrogen / Raney Ni / methanol / 24 h / 40 - 50 °C 2.1: water / ethanol / 36 h / 60 °C / Industry scale 3.1: toluene / 3 h / Industry scale; Reflux 4.1: methylamine / ethanol / 4 h / 65 °C / Industry scale 4.2: 58 - 60 °C / pH 2.7 / Industry scale 5.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Industry scale 5.2: 2.5 h / 0 - 25 °C View Scheme
参考文献
ENANTIA, S.L.; RAFECAS JANE, Llorenc; COMELY, Alexander Christian; FERRALI, Alessandro; AMELA CORTES, Celia; PASTO AGUILA, Mireia
Patent: WO2011/80341 A1, 2011 ;
反应条件
1: hydrogen / Raney Ni / methanol / 24 h / 40 - 50 °C 2: water / ethanol / 36 h / 60 °C / Industry scale View Scheme
参考文献
CADILA HEALTHCARE LIMITED; DWIVEDI, Shriprakash, Dhar; PRASAD, Ashok; PAL, Daya, Ram; SHARMA, Mukul, Hari, Prasad; JAIN, Kuldeep, Natwarlal; PATEL, Naitik, Bharatbhai
Patent: WO2013/98833 A2, 2013 ;
