4-(3-氧代-4-吗啉基)硝基苯合成路线 （共 13 条）
反应条件
sulfuric acid; nitric acid T=-10°C; 1 h;
参考文献
ENANTIA, S.L.; RAFECAS JANE, Llorenc; COMELY, Alexander Christian; FERRALI, Alessandro; AMELA CORTES, Celia; PASTO AGUILA, Mireia
Patent: WO2011/80341 A1, 2011 ;
Location in patent: Page/Page column 15 ;
反应条件
potassium permanganate; N-benzyl-N,N,N-triethylammonium chloride in dichloromethane T=20°C; 11 h; Heating / reflux;
参考文献
MERCK PATENT GMBH
Patent: WO2006/34789 A1, 2006 ;
Location in patent: Page/Page column 41 ;
反应条件
caesium carbonate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; palladium diacetate in 1,4-dioxane Sonographic reactionInert atmosphere;
参考文献
GALAPAGOS NV; MENET, Christel Jeanne Marie; BLANC, Javier; JOUANNIGOT, Nolwenn; HODGES, Alastair James; VAN ROMPAEY, Luc Juliaan Corina; FLETCHER, Stephen Robert
Patent: WO2010/10189 A1, 2010 ;
Location in patent: Page/Page column 55 ;
WO 2010/010189 A1
反应条件
in 1-methyl-pyrrolidin-2-one; water; ethyl acetate; paraffin
参考文献
Straub, Alexander; Lampe, Thomas; Pohlmann, Jens; Rohrig, Susanne; Perzborn, Elisabeth; Schlemmer, Karl-Heinz; Pernerstorfer, Joseph
Patent: US2003/153610 A1, 2003 ;
反应条件
potassium permanganate; sodium sulfate in water; 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran
参考文献
Aventis Pharma Deutschland GmbH
Patent: EP1571154 A1, 2005 ;
反应条件
potassium carbonate in acetonitrile T=20°C; 8 h;
参考文献
MERCK PATENT GMBH
Patent: WO2005/16899 A1, 2005 ;
Location in patent: Page/Page column 24 ;
反应条件
1: sodium hydroxide / ethanol; water / 0.5 h / 38 - 45 °C / pH 10 - 13 / Industry scale 2: nitric acid; sulfuric acid / sulfolane / 2 h / -5 - 30 °C View Scheme
参考文献
Li, Chao; Liu, Yingshuai; Zhang, Yongjun; Zhang, Xingxian
Journal of Chemical Research, 2011 , vol. 35, # 7 p. 400 - 401
反应条件
1: in acetonitrile T=80°C; 18 h; 2: With potassium carbonate in acetonitrile T=40°C; 14 h;
参考文献
MERCK PATENT GMBH
Patent: WO2005/16899 A1, 2005 ;
Location in patent: Page/Page column 26; 27 ;
反应条件
1: toluene / 5 h / 95 °C 2: K2CO3 / acetonitrile / 8 h / 20 °C View Scheme
参考文献
Mederski, Werner W.K.R.; Cezanne, Bertram; Amsterdam, Christoph Van; Buehring, Karl-Ulrich; Dorsch, Dieter; Gleitz, Johannes; Maerz, Joachim; Tsaklakidis, Christos
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 23 p. 5817 - 5822
反应条件
hydrogen; palladium on activated charcoal in methanol; water T=40°C; P=1500.15 Torr; 17 h;
参考文献
Mederski, Werner W.K.R.; Wendel, Peter Ludwig; Woissyk, Markus
Heterocycles, 2007 , vol. 74, # C p. 437 - 445
