4'-氟-2'-甲基苯乙酮合成路线 （共 9 条）
反应条件
potassium carbonate; 1,3-bis-(diphenylphosphino)propane; palladium diacetate in DMF (N,N-dimethyl-formamide) T=80°C; 48 h;
参考文献
US2005/101586 A1, ;
Page/Page column 9 ;
反应条件
pyridinium chlorochromate in dichloromethane T=25°C; 1 h; Inert atmosphereSchlenk technique;
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 1 p. 84 - 96
反应条件
aluminium trichloride in carbon disulfide
参考文献
Heterocycles, , vol. 16, # 9 p. 1545 - 1553
反应条件
1: tetrahydrofuran / 1 h / -78 - 25 °C / |Inert atmosphere; |Schlenk technique 2: pyridinium chlorochromate / dichloromethane / 1 h / 25 °C / |Inert atmosphere; |Schlenk technique View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 1 p. 84 - 96
反应条件
aluminium trichloride in carbon disulfide Heating;
参考文献
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , p. 119 - 125
参考文献
Buu-Hoi; Xuong
Journal of the Chemical Society, 1953 , p. 386
反应条件
1: 80 percent / selenium dioxide / dioxane; H2O / 6 h / Heating
2: ethanol; H2O / 0.17 h / Heating
3: potassium carbonate / ethanol; H2O / 8 h / Heating
View Scheme
参考文献
Joshi, Krishna C.; Dubey, Kalpana; Dandia, Anshu
Heterocycles, 1981 , vol. 16, # 9 p. 1545 - 1553
反应条件
titanium tetrachloride in hexane
T=0 - 20°C; 15.5 h;
参考文献
ALTANA PHARMA AG
Patent: WO2006/136552 A2, 2006 ;
Location in patent: Page/Page column 96 ;
反应条件
1: aluminium isopropylate; isopropyl alcohol
2: KHSO4 / 230 °C / 70 Torr
View Scheme
参考文献
Sianesi
Gazzetta Chimica Italiana, 1959 , vol. 89, p. 1749,1759
