4-氨基-2-氟-5-硝基苯甲醚合成路线 （共 6 条）
反应条件
hydrogenchloride; ethanol
0.5 h; Heating / reflux;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2005/82879 A1, 2005 ;
Location in patent: Page/Page column 96-97 ;
WO 2005/082879 A1
反应条件
1: acetic acid anhydride; glacial acetic acid; HNO3 / -10 - 0 °C
2: platinum / Hydrogenation
3: concentrated sulfuric acid; water; nitric acid
4: aq.-ethanolic hydrochloric acid
View Scheme
参考文献
Elderfield et al.
Journal of the American Chemical Society, 1946 , vol. 68, p. 1583
Chem.Abstr., 1947 , p. 6274
反应条件
1: platinum / Hydrogenation
2: concentrated sulfuric acid; water; nitric acid
3: aq.-ethanolic hydrochloric acid
View Scheme
参考文献
Elderfield et al.
Journal of the American Chemical Society, 1946 , vol. 68, p. 1583
Chem.Abstr., 1947 , p. 6274
反应条件
1: concentrated sulfuric acid; water; nitric acid
2: aq.-ethanolic hydrochloric acid
View Scheme
参考文献
Elderfield et al.
Journal of the American Chemical Society, 1946 , vol. 68, p. 1583
Chem.Abstr., 1947 , p. 6274
反应条件
1: With hydrogen bromide in 1,4-dioxane; water
0.25 h; Heating / reflux;
2: With copper(I) bromide; sodium nitrite in 1,4-dioxane; water
T=0 - 60°C; 1.5 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2005/82879 A1, 2005 ;
Location in patent: Page/Page column 97-98 ;
WO 2005/082879 A1
反应条件
diarsenic pentoxide; sulfuric acid
T=130 - 140°C;
参考文献
Elderfield et al.
Journal of the American Chemical Society, 1946 , vol. 68, p. 1583
Chem.Abstr., 1947 , p. 6274
