3-氯-4-三氟甲基苯胺合成路线 （共 11 条）
反应条件
2-picoline; Na2S2O5; sulfur dioxide; zinc in N,N-dimethyl-formamide T=65°C; P=2250.2 - 3750.3 Torr; 3 h;
参考文献
Tordeux, Marc; Langlois, Bernard; Wakselman, Claude
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 8 p. 2293 - 2299
参考文献
Bayer Aktiengesellschaft
Patent: US4162329 A1, 1979 ;
参考文献
Gen.Aniline Works
Patent: US2093115 , 1936 ;
Full Text Show Details
I.G.Farbenind.
Patent: DE672371 , 1935 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 25, p. 119
参考文献
Bloom, Jonathan D.; DiGrandi, Martin J.; Dushin, Russell G.; Curran, Kevin J.; Ross, Adma A.; Norton, Emily B.; Terefenko, Eugene; Jones, Thomas R.; Feld, Boris; Lang, Stanley A.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 17 p. 2929 - 2932
参考文献
Bloom, Jonathan D.; DiGrandi, Martin J.; Dushin, Russell G.; Curran, Kevin J.; Ross, Adma A.; Norton, Emily B.; Terefenko, Eugene; Jones, Thomas R.; Feld, Boris; Lang, Stanley A.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 17 p. 2929 - 2932
反应条件
tert.-butylnitrite; copper(ll) bromide in acetonitrile T=45°C; 3 h;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2008/78291 A1, 2008 ;
Location in patent: Page/Page column 42 ;
WO 2008/078291 A1
反应条件
1: With sodium nitrite in water; acetic acid; acetonitrile T=0°C; 0.416667 h; 2: With sulfur dioxide; copper dichloride in water; acetic acid; acetonitrile T=10°C;
参考文献
Amgen Inc.; Array Biopharma, Inc.
Patent: US2005/234044 A1, 2005 ;
Location in patent: Page/Page column 42-43 ;
US 20050234044 A1
反应条件
1: 3-Chloro-4-trifluoromethyl-phenylamine With hydrogenchloride; sodium nitrite in water; acetic acid T=0°C; 0.45 h; 2: sulfur dioxide With copper dichloride in water; acetic acid T=20°C;
参考文献
AMGEN, INC.; ARRAY BIOPHARMA, INC.
Patent: WO2004/92164 A1, 2004 ;
Location in patent: Page 123; 124 ;
WO 2004/092164 A1
反应条件
1: 12 h / 25 °C 2: concd. H2SO4, concd. HNO3 / 0 - 20 °C 3: concd. HCl / Heating View Scheme
参考文献
Keana; Kher; Sui Xiong Cai; Dinsmore; Glenn; Guastella; Huang; Ilyin; Lu; Mouser; Woodward; Weber
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4367 - 4379
反应条件
1: 12 h / 25 °C 2: concd. H2SO4, concd. HNO3 / 0 - 20 °C 3: concd. HCl / Heating 4: SnCl2*H2O / ethyl acetate; ethanol / 0.58 h / 70 °C View Scheme
参考文献
Keana; Kher; Sui Xiong Cai; Dinsmore; Glenn; Guastella; Huang; Ilyin; Lu; Mouser; Woodward; Weber
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4367 - 4379
