6-氯-5-碘吡啶-3-胺合成路线 （共 5 条）
反应条件
iron; acetic acid in water T=70°C; 1 h;
参考文献
Dolle, Frederic; Langle, Sandrine; Roger, Gaelle; Fulton, Roger R.; Lagnel-De Bruin, Beatrice; Henderson, David J.; Hinnen, Francoise; Paine, Taliesha; Coster, Mark J.; Valette, Heric; Bottlaender, Michel; Kassiou, Michael
Australian Journal of Chemistry, 2008 , vol. 61, # 6 p. 438 - 445
反应条件
1: 45 percent / I2; K2CO3 / dimethylformamide / 8 h / 80 - 95 °C 2: 78 percent / POCl3; quinoline / 2 h / 120 °C 3: 68 percent / iron; aq. AcOH / 65 - 85 °C View Scheme
参考文献
Brown, LaVerne L.; Kulkarni, Santosh; Pavlova, Olga A.; Koren, Andrei O.; Mukhin, Alexey G.; Newman, Amy H.; Horti, Andrew G.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 13 p. 2841 - 2849
参考文献
Salvati, Mark E.; Balog, James Aaron; Pickering, Dacia A.; Giese, Soren; Fura, Aberra; Li, Wenying; Patel, Ramesh N.; Hanson, Ronald L.; Mitt, Toomas; Roberge, Jacques Y.; Corte, James R.; Spergel, Steven H.; Rampulla, Richard A.; Misra, Raj N.; Xiao, Hai-Yun
Patent: US2004/77605 A1, 2004 ;
US 20040077605 A1
反应条件
1: 78 percent / POCl3; quinoline / 2 h / 120 °C 2: 68 percent / iron; aq. AcOH / 65 - 85 °C View Scheme
参考文献
Brown, LaVerne L.; Kulkarni, Santosh; Pavlova, Olga A.; Koren, Andrei O.; Mukhin, Alexey G.; Newman, Amy H.; Horti, Andrew G.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 13 p. 2841 - 2849
反应条件
1.1: HBF4; aq. NaNO2 / 1 h / 0 °C
1.2: 72 percent / 70 - 85 °C
2.1: 63 percent / 2 N aq. KOH / 24 h
View Scheme
参考文献
Brown, LaVerne L.; Kulkarni, Santosh; Pavlova, Olga A.; Koren, Andrei O.; Mukhin, Alexey G.; Newman, Amy H.; Horti, Andrew G.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 13 p. 2841 - 2849
