2-(4-氯苯基)-2-羟基丙酸合成路线

4445-13-02-(4-氯苯基)-2-羟基丙酸→938-95-44-(氯甲基)苯乙酸

参考文献

Aramini, Andrea; Sablone, Manolo R.; Bianchini, Gianluca; Amore, Alessia; Fani, Michela; Perrone, Plinio; Dolce, Alberto; Allegretti, Marcello
Tetrahedron, 2009 , vol. 65, # 10 p. 2015 - 2021

102877-35-0→

参考文献

Gancitano, Pamela; Ciriminna, Rosaria; Testa, Maria Luisa; Fidalgo, Alexandra; Ilharco, Laura M.; Pagliaro, Mario
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 13 p. 2389 - 2392

75-69-4一氟三氯甲烷+99-91-2对氯苯乙酮→938-95-44-(氯甲基)苯乙酸+93900-78-8+4445-13-02-(4-氯苯基)-2-羟基丙酸

参考文献

Garcia, Mariano; Del Campo, Carmen; Sinisterra, Jose V.; Llama, Emilio F.
Tetrahedron Letters, 1993 , vol. 34, # 49 p. 7973 - 7974

1310-66-3单水氢氧化锂+100126-96-3→4445-13-02-(4-氯苯基)-2-羟基丙酸

参考文献

Syngenta Participations AG
Patent: US6469005 B1, 2002 ;

53066-09-4→4445-13-02-(4-氯苯基)-2-羟基丙酸+99-91-2对氯苯乙酮

参考文献

Aramini, Andrea; Sablone, Manolo R.; Bianchini, Gianluca; Amore, Alessia; Fani, Michela; Perrone, Plinio; Dolce, Alberto; Allegretti, Marcello
Tetrahedron, 2009 , vol. 65, # 10 p. 2015 - 2021

67-66-3氯仿+99-91-2对氯苯乙酮→4445-13-02-(4-氯苯基)-2-羟基丙酸

参考文献

Garcia; Del Campo; Llama; Sanchez-Montero; Sinisterra
Tetrahedron, 1993 , vol. 49, # 37 p. 8433 - 8440

917-64-6magnesium,carbanide,iodide+7099-88-9(4-氯苯基)乙醛酸→4445-13-02-(4-氯苯基)-2-羟基丙酸

参考文献

Geffken; Frobose
Pharmazie, 1994 , vol. 49, # 12 p. 889 - 893

102877-35-0→4445-13-02-(4-氯苯基)-2-羟基丙酸

参考文献

Weaver, Jimmie D.; Ka, Being J.; Morris, David K.; Thompson, Ward; Tunge, Jon A.
Journal of the American Chemical Society, 2010 , vol. 132, # 35 p. 12179 - 12181

127-17-3丙酮酸+873-77-84-氯苯基溴化镁→4445-13-02-(4-氯苯基)-2-羟基丙酸

参考文献

Skerrett; Woodcock
Journal of the Chemical Society, 1952 , p. 2806,2808