1: Desmethylnortriptyline With sodium hydride in N,N-dimethyl-formamide; mineral oil 0.333333 h; 2: methyl iodide in N,N-dimethyl-formamide; mineral oil T=20°C; 4 h;
cDNA-expressed human cytochrome P450 (CYP) 1A2 enzyme in water
T=37°C; demethylation; pH=7.4; 0.25 h; Enzymatic reaction; Enzyme kinetics; Further Variations:Reagents;
参考文献
Olesen, Ole V.; Linnet, Kristian
Pharmacology, 1997 , vol. 55, # 5 p. 235 - 243
