2-氯-4-(2,2,2-三氟乙氧基)苯酚合成路线 （共 6 条）
反应条件
N,N-diisopropylmethyl amine; sulfuryl dichloride in toluene
T=25°C; 2 h;
参考文献
Shi, Guo Q.; Dropinski, James F.; Zhang, Yong; Santini, Conrad; Sahoo, Soumya P.; Berger, Joel P.; MacNaul, Karen L.; Zhou, Gaochao; Agrawal, Arun; Alvaro, Raul; Cai, Tian-Quan; Hernandez, Melba; Wright, Samuel D.; Moller, David E.; Heck, James V.; Meinke, Peter T.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 17 p. 5589 - 5599
反应条件
sulfuryl dichloride in toluene
参考文献
Sahoo, Soumya P.; Koyama, Hiroo; Miller, Daniel J.; Boueres, Julia K.; Desai, Ranjit C.
Patent: US2002/103242 A1, 2002 ;
反应条件
1: 95 percent / H2 / Pd/C
2: SO2Cl2; diisobutylamine
View Scheme
参考文献
Koyama, Hiroo; Boueres, Julia K.; Miller, Daniel J.; Berger, Joel P.; MacNaul, Karen L.; Wang, Pei-Ran; Ippolito, Marc C.; Wright, Samuel D.; Agrawal, Arun K.; Moller, David E.; Sahoo, Soumya P.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 14 p. 3347 - 3351
反应条件
1: Cs2CO3
2: 95 percent / H2 / Pd/C
3: SO2Cl2; diisobutylamine
View Scheme
参考文献
Koyama, Hiroo; Boueres, Julia K.; Miller, Daniel J.; Berger, Joel P.; MacNaul, Karen L.; Wang, Pei-Ran; Ippolito, Marc C.; Wright, Samuel D.; Agrawal, Arun K.; Moller, David E.; Sahoo, Soumya P.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 14 p. 3347 - 3351
反应条件
caesium carbonate in N,N-dimethyl-formamide
T=60°C; 5 h;
参考文献
Shi, Guo Q.; Dropinski, James F.; Zhang, Yong; Santini, Conrad; Sahoo, Soumya P.; Berger, Joel P.; MacNaul, Karen L.; Zhou, Gaochao; Agrawal, Arun; Alvaro, Raul; Cai, Tian-Quan; Hernandez, Melba; Wright, Samuel D.; Moller, David E.; Heck, James V.; Meinke, Peter T.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 17 p. 5589 - 5599
反应条件
1: Cs2CO3 / dimethylformamide / 5 h / 60 °C
2: triphenylphosphine; imidazole; iodine / CH2Cl2 / 1 h / 25 °C
View Scheme
参考文献
Shi, Guo Q.; Dropinski, James F.; Zhang, Yong; Santini, Conrad; Sahoo, Soumya P.; Berger, Joel P.; MacNaul, Karen L.; Zhou, Gaochao; Agrawal, Arun; Alvaro, Raul; Cai, Tian-Quan; Hernandez, Melba; Wright, Samuel D.; Moller, David E.; Heck, James V.; Meinke, Peter T.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 17 p. 5589 - 5599
