(5R)-3-(4-溴-3-氟苯基)-5-羟甲基恶唑烷-2-酮合成路线 （共 5 条）
反应条件
lithium tert-butylate in tetrahydrofuran; methanol; N,N-dimethyl-formamide T=0 - 20°C; 3 h;
参考文献
LegoChem Biosciences, Inc.; CHO, Young Lag; BAEK, Sung Yoon; CHAE, Sang Eun; KIM, Sun Young; LEE, Hong Bum; LEE, Hyang Sook; OH, Kyuman; HEO, Hye Jin; PARK, Tae Kyo; WOO, Sung Ho; KIM, Yong Zu
Patent: EP2692727 A2, 2014 ;
Location in patent: Paragraph 0161-0162 ;
反应条件
bromine in chloroform T=20°C;
参考文献
GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT
Patent: WO2009/120789 A1, 2009 ;
Location in patent: Page/Page column 58 ;
反应条件
1: 2-methylpropyl (4-bromo-3-fluorophenyl)carbamate With lithium tert-pentoxide in tetrahydrofuran T=-15°C; 2: (S)-1-chloro-2,3-dihydroxypropane With potassium tert-butylate in tetrahydrofuran T=-25 - 10°C;
参考文献
Gordeev, Mikhail F.; Patel, Dinesh V.; Barbachyn, Michael R.; Gage, James R.
Patent: US2003/13737 A1, 2003 ;
反应条件
1: sodium hydroxide / dichloromethane / 1 h / 20 °C 2: lithium tert-butylate / N,N-dimethyl-formamide; methanol; tetrahydrofuran / 3 h / 0 - 20 °C View Scheme
参考文献
LegoChem Biosciences, Inc.; CHO, Young Lag; BAEK, Sung Yoon; CHAE, Sang Eun; KIM, Sun Young; LEE, Hong Bum; LEE, Hyang Sook; OH, Kyuman; HEO, Hye Jin; PARK, Tae Kyo; WOO, Sung Ho; KIM, Yong Zu
Patent: EP2692727 A2, 2014 ;
反应条件
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.33 h / 0 - 20 °C 2.1: sodium azide / N,N-dimethyl-formamide / 3 h / 90 °C 3.1: iron; ammonium chloride / water; ethanol / 12 h / |Reflux 3.2: 1 h / 20 °C View Scheme
参考文献
LEGOCHEM BIOSCIENCES, INC.; Cho, Young Lag; Baek, Sung Yoon; Chae, Sang Eun; Kim, Sun Young; Lee, Hong Bum; Lee, Hyang Sook; Oh, Kyuman; Park, Tae Kyo; Woo, Sung Ho; Kim, Yong Zu; Heo, Hye Jin
Patent: US2014/179691 A1, 2014 ;
