2-(1,3-二氧代-1,3-二氢-2H-异吲哚-2-基)乙烷磺酰胺合成路线 （共 5 条）
反应条件
hydrazine hydrate in ethanol
参考文献
Smits, Rogier A.; Adami, Maristella; Istyastono, Enade P.; Zuiderveld, Obbe P.; Van Dam, Cindy M. E.; De Kanter, Frans J. J.; Jongejan, Aldo; Coruzzi, Gabriella; Leurs, Rob; De Esch, Iwan J. P.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 6 p. 2390 - 2400
反应条件
ammonia in dichloromethane
T=0 - 20°C;
参考文献
Usifoh, Cyril O.; Lambert, Didier M.; Wouters, Johan; Scriba, Gerhard K.E.
Archiv der Pharmazie, 2001 , vol. 334, # 10 p. 323 - 331
反应条件
1: 90 percent / CH3COOK, AcOH
2: 85 percent / PCl5 / benzene
3: 70 percent / NH3 / tetrahydrofuran / 0 °C
View Scheme
参考文献
Shin, Kye Jung; Yoo, Kyung Ho; Kim, Dong Jin; Park, Sang Woo; Ko, Bong Suck; Lee, Sang Joo; Huh, Jae Doo; Park, Seung Yong
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 13 p. 1607 - 1612
反应条件
1: 85 percent / PCl5 / benzene
2: 70 percent / NH3 / tetrahydrofuran / 0 °C
View Scheme
参考文献
Shin, Kye Jung; Yoo, Kyung Ho; Kim, Dong Jin; Park, Sang Woo; Ko, Bong Suck; Lee, Sang Joo; Huh, Jae Doo; Park, Seung Yong
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 13 p. 1607 - 1612
反应条件
1: With hydrazine in ethanol; water
3 h; Heating / reflux;
2: With hydrogenchloride in water
参考文献
Vereniging voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek en Patientenzorg
Patent: EP2077263 A1, 2009 ;
Location in patent: Page/Page column 15-16 ;
EP 2077263 A1
