NaBH(OAc)3; acetic acid in methanol; dichloromethane; water T=20°C; 2 h;

1: With formic acid in water T=80°C; 6.5 - 8.5 h; 2: With potassium hydroxide in methanol; water T=60°C; 2 h; Product distribution / selectivity;

in isopropyl alcohol T=80°C; 0.533333 h; Microwave irradiation;

1: hydrogenchloride / isopropyl alcohol / 2 h / Reflux 2: trifluoroacetic acid / 1 h / Reflux 3: potassium carbonate / N,N-dimethyl-formamide / 20 - 90 °C 4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C 5: NaBH(OAc)3; acetic acid / methanol; dichloromethane; water / 2 h / 20 °C View Scheme

1: hydrogenchloride / isopropyl alcohol / 2 h / Reflux 2: trifluoroacetic acid / 1 h / Reflux 3: potassium carbonate / N,N-dimethyl-formamide / 20 - 90 °C 4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C 5: NaBH(OAc)3; acetic acid / methanol; dichloromethane; water / 2 h / 20 °C View Scheme

1: potassium carbonate / N,N-dimethyl-formamide / 20 - 90 °C 2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C 3: NaBH(OAc)3; acetic acid / methanol; dichloromethane; water / 2 h / 20 °C View Scheme

1: trifluoroacetic acid / 1 h / Reflux 2: potassium carbonate / N,N-dimethyl-formamide / 20 - 90 °C 3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C 4: NaBH(OAc)3; acetic acid / methanol; dichloromethane; water / 2 h / 20 °C View Scheme