八氢吡啶并[1,2-a]吡嗪合成路线 （共 11 条）
反应条件
hydrogen; palladium on activated charcoal in methanol T=20°C; 4 h;
参考文献
MEMORY PHARMACEUTICALS CORPORATION
Patent: US2008/200471 A1, 2008 ;
Location in patent: Page/Page column 39; 40 ;
US 20080200471 A1
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 4 h;
参考文献
Hoeglund, Iisa P. J.; Silver, Satu; Engstroem, Mia T.; Salo, Harri; Tauber, Andrei; Kyyroenen, Hanna-Kaisa; Saarenketo, Pauli; Hoffren, Anna-Marja; Kokko, Kurt; Pohjanoksa, Katariina; Sallinen, Jukka; Savola, Juha-Matti; Wurster, Siegfried; Kallatsa, Oili A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6351 - 6363
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 0.166667 h; Heating;
参考文献
Costa, Brian R. de; He, Xiao-shu; Linders, Joannes T.M.; Dominguez, Celia; Gu, Zi Qiang; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 16 p. 2311 - 2320
反应条件
1: hydrazine hydrate / methanol 2: 397 mg / LiAlH4 / tetrahydrofuran / 4 h / 20 °C View Scheme
参考文献
Hoeglund, Iisa P. J.; Silver, Satu; Engstroem, Mia T.; Salo, Harri; Tauber, Andrei; Kyyroenen, Hanna-Kaisa; Saarenketo, Pauli; Hoffren, Anna-Marja; Kokko, Kurt; Pohjanoksa, Katariina; Sallinen, Jukka; Savola, Juha-Matti; Wurster, Siegfried; Kallatsa, Oili A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6351 - 6363
反应条件
1.1: triflic anhydride / CH2Cl2 / 0.17 h / 0 °C 1.2: 98 percent / 2,6-lutidine; TEA / CH2Cl2 / 20 °C 2.1: hydrazine hydrate / methanol 3.1: 397 mg / LiAlH4 / tetrahydrofuran / 4 h / 20 °C View Scheme
参考文献
Hoeglund, Iisa P. J.; Silver, Satu; Engstroem, Mia T.; Salo, Harri; Tauber, Andrei; Kyyroenen, Hanna-Kaisa; Saarenketo, Pauli; Hoffren, Anna-Marja; Kokko, Kurt; Pohjanoksa, Katariina; Sallinen, Jukka; Savola, Juha-Matti; Wurster, Siegfried; Kallatsa, Oili A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6351 - 6363
反应条件
ammonia in methanol; water
参考文献
ASTRAZENECA AB
Patent: US2008/153812 A1, 2008 ;
Location in patent: Page/Page column 122 ;
US 20080153812 A1
参考文献
Winterfeld; Gierenz
Chemische Berichte, 1959 , vol. 92, p. 240,244
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide
Heating;
参考文献
Shukla, U. K.; Khanna, J. M.; Sharma, Satyavan; Anand, Nitya; Chatterjee, R. K.; Sen, A. B.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 7 p. 664 - 668
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide
Heating;
参考文献
Shukla, U. K.; Khanna, J. M.; Sharma, Satyavan; Anand, Nitya; Chatterjee, R. K.; Sen, A. B.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 7 p. 664 - 668
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide
Heating;
参考文献
Shukla, U. K.; Khanna, J. M.; Sharma, Satyavan; Anand, Nitya; Chatterjee, R. K.; Sen, A. B.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 7 p. 664 - 668
