2-氧杂-8-氮杂螺[4.5]癸烷-1-酮盐酸盐合成路线

154348-08-01-氧代-2-噁-8-氮杂螺[4.5]癸烷-8-羧酸叔丁酯→4427-25-22-氧杂-8-氮杂螺[4.5]癸烷-1-酮盐酸盐

参考文献

Cooper, Laura C.; Carlson, Emma J.; Castro, Jose L.; Chicchi, Gary G.; Dinnell, Kevin; Di Salvo, Jerry; Elliott, Jason M.; Hollingworth, Gregory J.; Kurtz, Marc M.; Ridgill, Mark P.; Rycroft, Wayne; Tsao, Kwei-Lan; Swain, Christopher J.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 13 p. 1759 - 1762

142851-03-4N-Boc-4-哌啶甲酸乙酯→4427-25-22-氧杂-8-氮杂螺[4.5]癸烷-1-酮盐酸盐

参考文献

Cooper, Laura C.; Carlson, Emma J.; Castro, Jose L.; Chicchi, Gary G.; Dinnell, Kevin; Di Salvo, Jerry; Elliott, Jason M.; Hollingworth, Gregory J.; Kurtz, Marc M.; Ridgill, Mark P.; Rycroft, Wayne; Tsao, Kwei-Lan; Swain, Christopher J.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 13 p. 1759 - 1762

146603-99-81-Boc-4-烯丙基-4-哌啶甲酸乙酯→4427-25-22-氧杂-8-氮杂螺[4.5]癸烷-1-酮盐酸盐

参考文献

Cooper, Laura C.; Carlson, Emma J.; Castro, Jose L.; Chicchi, Gary G.; Dinnell, Kevin; Di Salvo, Jerry; Elliott, Jason M.; Hollingworth, Gregory J.; Kurtz, Marc M.; Ridgill, Mark P.; Rycroft, Wayne; Tsao, Kwei-Lan; Swain, Christopher J.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 13 p. 1759 - 1762

247133-32-04-(2-羟基乙基)-1,4-哌啶二羧酸 1-(1,1-二甲基乙基) 4-乙酯→4427-25-22-氧杂-8-氮杂螺[4.5]癸烷-1-酮盐酸盐

参考文献

Cooper, Laura C.; Carlson, Emma J.; Castro, Jose L.; Chicchi, Gary G.; Dinnell, Kevin; Di Salvo, Jerry; Elliott, Jason M.; Hollingworth, Gregory J.; Kurtz, Marc M.; Ridgill, Mark P.; Rycroft, Wayne; Tsao, Kwei-Lan; Swain, Christopher J.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 13 p. 1759 - 1762

40118-04-5→4427-25-22-氧杂-8-氮杂螺[4.5]癸烷-1-酮盐酸盐

参考文献

Eckhardt,W. et al.
Helvetica Chimica Acta, 1972 , vol. 55, p. 2432 - 2438