1: 87 percent / NaH; Bu4NI / tetrahydrofuran / 24 h / 20 °C 2: 84 percent / aq. HCl / methanol / 2 h / Heating 3: 73 percent / Cs2CO3 / acetonitrile / 1 h / -40 °C 4: 92 percent / NaH; Bu4NI / tetrahydrofuran / 24 h / 20 °C 5: 90 percent / KOH / methanol / 2 h / 50 °C 6: 97 percent / Cs2CO3 / acetonitrile / 24 h / 20 °C 7: 92 percent / H2 / Pd-C / ethyl acetate / 24 h / 20 °C 8: 92 percent / KOH / methanol / 1 h / 20 °C 9: aq. HCl / methanol / 3 h / Heating View Scheme

1: 73 percent / Cs2CO3 / acetonitrile / 1 h / -40 °C 2: 92 percent / NaH; Bu4NI / tetrahydrofuran / 24 h / 20 °C 3: 90 percent / KOH / methanol / 2 h / 50 °C 4: 97 percent / Cs2CO3 / acetonitrile / 24 h / 20 °C 5: 92 percent / H2 / Pd-C / ethyl acetate / 24 h / 20 °C 6: 92 percent / KOH / methanol / 1 h / 20 °C 7: aq. HCl / methanol / 3 h / Heating View Scheme

1: 92 percent / NaH; Bu4NI / tetrahydrofuran / 24 h / 20 °C 2: 90 percent / KOH / methanol / 2 h / 50 °C 3: 97 percent / Cs2CO3 / acetonitrile / 24 h / 20 °C 4: 92 percent / H2 / Pd-C / ethyl acetate / 24 h / 20 °C 5: 92 percent / KOH / methanol / 1 h / 20 °C 6: aq. HCl / methanol / 3 h / Heating View Scheme

1: 84 percent / aq. HCl / methanol / 2 h / Heating 2: 73 percent / Cs2CO3 / acetonitrile / 1 h / -40 °C 3: 92 percent / NaH; Bu4NI / tetrahydrofuran / 24 h / 20 °C 4: 90 percent / KOH / methanol / 2 h / 50 °C 5: 97 percent / Cs2CO3 / acetonitrile / 24 h / 20 °C 6: 92 percent / H2 / Pd-C / ethyl acetate / 24 h / 20 °C 7: 92 percent / KOH / methanol / 1 h / 20 °C 8: aq. HCl / methanol / 3 h / Heating View Scheme

1: 97 percent / Cs2CO3 / acetonitrile / 24 h / 20 °C 2: 92 percent / H2 / Pd-C / ethyl acetate / 24 h / 20 °C 3: 92 percent / KOH / methanol / 1 h / 20 °C 4: aq. HCl / methanol / 3 h / Heating View Scheme

1: 90 percent / KOH / methanol / 2 h / 50 °C 2: 97 percent / Cs2CO3 / acetonitrile / 24 h / 20 °C 3: 92 percent / H2 / Pd-C / ethyl acetate / 24 h / 20 °C 4: 92 percent / KOH / methanol / 1 h / 20 °C 5: aq. HCl / methanol / 3 h / Heating View Scheme

1: 92 percent / H2 / Pd-C / ethyl acetate / 24 h / 20 °C 2: 92 percent / KOH / methanol / 1 h / 20 °C 3: aq. HCl / methanol / 3 h / Heating View Scheme

hydrogenchloride in methanol 3 h; Heating;

1: 92 percent / KOH / methanol / 1 h / 20 °C 2: aq. HCl / methanol / 3 h / Heating View Scheme

hydrogenchloride in ethanol Heating;