吡啶 4-(4-甲基苯基)-合成路线 （共 36 条）
反应条件
sulfuric acid; ozone; acetic acid; Manganese (II) acetate T=16°C; 1 h;
参考文献
Jary, Walther; Poechlauer, Peter; Ganglberger, Thorsten
Patent: US2003/216577 A1, 2003 ;
Location in patent: Page/Page column 5 ;
反应条件
1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in o-di-fluorobenzene; dimethyl sulfoxide T=90°C; 36 h;
参考文献
Nicolaou; Baran; Zhong
Journal of the American Chemical Society, 2001 , vol. 123, # 13 p. 3183 - 3185
反应条件
Pd(PPh2)(m-C6H4SO3Na)*(H2O)4; sodium carbonate in methanol; water; benzene
T=80°C; 6.5 h;
参考文献
Casalnuovo, Albert L.; Calabrese, Joseph C.
Journal of the American Chemical Society, 1990 , vol. 112, # 11 p. 4324 - 4330
反应条件
Na2[PdCl4]; cataCXium FSulf; potassium carbonate in water; butan-1-ol
T=100°C; Suzuki coupling; 12 h; Inert atmosphere;
参考文献
Fleckenstein, Christoph A.; Plenio, Herbert
Chemistry - A European Journal, 2008 , vol. 14, # 14 p. 4267 - 4279
反应条件
C18H20Cl2N8Pd; caesium carbonate in 1,4-dioxane
T=100°C; Suzuki coupling; 12 h; Inert atmosphere;
参考文献
Xu, Chen; Li, Zhen; Duan, Lu-Meng; Wang, Zhi-Qiang; Fu, Wei-Jun; Hao, Xin-Qi; Song, Mao-Ping
Transition Metal Chemistry, 2012 , vol. 37, # 4 p. 373 - 378
反应条件
potassium hydroxide; tetrabutylammomium bromide; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
3.5 h; Heating;
参考文献
Ishikura; Ohta; Terashima
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 11 p. 4755 - 4763
反应条件
1: 4-hydroxy-pyridine With potassium phosphate; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate in 1,4-dioxane; N,N-dimethyl-formamide
T=100°C; 3 h; Inert atmosphere;
2: p-methylphenylboronic acid With [1,3-bis(diphenylphosphino) propane] dichloronickel(II) in 1,4-dioxane; N,N-dimethyl-formamide
T=100 - 110°C; Suzuki-Miyaura coupling; Inert atmosphere;
参考文献
Chen, Guo-Jun; Huang, Jie; Gao, Lian-Xun; Han, Fu-She
Chemistry - A European Journal, 2011 , vol. 17, # 14 p. 4038 - 4042
反应条件
C52H44CoN4O4; potassium hydroxide; tert-butyl alcohol
T=200°C; 6 h; Inert atmosphereDarkness;
参考文献
Qian, Ying Ying; Wong, Ka Lai; Zhang, Meng Wen; Kwok, Tsz Yiu; To, Ching Tat; Chan, Kin Shing
Tetrahedron Letters, 2012 , vol. 53, # 13 p. 1571 - 1575
反应条件
[NiCl2(PMe3)2] in tetrahydrofuran
T=25°C; 12 h; Inert atmosphere;
参考文献
Liu, Ning; Wang, Zhong-Xia
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 9 p. 1641 - 1645
反应条件
copper(l) iodide; cesium fluoride in N,N-dimethyl-formamide
T=120°C; Hiyama Coupling; 12 h; Inert atmosphere;
参考文献
Gurung, Santosh K.; Thapa, Surendra; Vangala, Adarsh S.; Giri, Ramesh
Organic Letters, 2013 , vol. 15, # 20 p. 5378 - 5381
