3-苯基丙-2-烯-1-醇合成路线 （共 318 条）
反应条件
Multi-step reaction with 5 steps 1: MCPBA / CH2Cl2 / 0 deg C, 1.5 h, then RT, 24 h2: 1.) NaOH / 1.) H2O, 70 deg C; 2.) H2O, 70 deg C, 2.5 h3: 67 percent / pyridine / -10 deg C, 2 h, then RT, 2 h4: 83 percent / 30percent NH4OH / N,N-dimethyl-acetamide / Ambient temperature; sealed flask5: 79 percent / Et3N / CH2Cl2 / 0.5 h / -10 - -5 °C
参考文献
Melloni; Della Torre; Lazzari; et al. Tetrahedron, 1985 , vol. 41, # 7 p. 1393 - 1399
反应条件
Multi-step reaction with 2 steps 1: NaH / tetrahydrofuran / 4 h / 20 °C2: tetrahydrofuran / 2 h / -78 - -20 °C
参考文献
McNally, Andrew; Evans, Brian; Gaunt, Matthew J. Angewandte Chemie - International Edition, 2006 , vol. 45, # 13 p. 2116 - 2119
反应条件
Multi-step reaction with 3 steps 1: 78 percent / pyridine / CH2Cl2 / 3 h / 0 - 20 °C2: 63 percent / 1,2-bis(diphenylphosphino)ethane / tetrakis(triphenylphosphine)palladium(0) / tetrahydrofuran / 24 h / 20 °C3: 52 percent / aq. HCl / diethyl ether / 1 h
参考文献
Knight; Redfern; Gilmore Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 21 p. 2874 - 2883
反应条件
With 1-n-butyl-3-methylimidazolium hexafluorophosphate; 2,2-difluoro-1,3-dimethylimidazollidine T=20°C; 7 h;
参考文献
Kitazume, Tomoya; Ebata, Takuma Journal of Fluorine Chemistry, 2004 , vol. 125, # 10 p. 1509 - 1511
反应条件
With chloro-trimethyl-silane in tetrachloromethane T=20°C; 2 h;
参考文献
Macia, Beatriz; Gomez, Cecilia; Yus, Miguel Tetrahedron Letters, 2005 , vol. 46, # 36 p. 6101 - 6104
反应条件
Multi-step reaction with 2 steps 1: 87 percent / NEt3 / acetonitrile / 24 h / Ambient temperature2: DPPE / Pd(dba)2 / tetrahydrofuran / 1 h / Heating
参考文献
Takeda, Kazuyoshi; Tsuboyama, Kanoko; Torii, Katsumi; Murata, Maki; Ogura, Haruo Tetrahedron Letters, 1988 , vol. 29, # 33 p. 4105 - 4108
反应条件
Multi-step reaction with 2 steps 1: 82 percent / tert-butyl hydroperoxide; (-)-diethyl D-tartarate; molecular sieves 4 Angstroem / titanium(IV) isopropoxide / CH2Cl2; toluene / 4 h / -23 °C2: oxalyl chloride; dimethylsulfoxide; triethylamine / CH2Cl2 / -78 - 0 °C
参考文献
Yadav, Jhillu Singh; Raju, Atcha Krishnam; Rao, Ponugoti Purushothama; Rajaiah, Gurram Tetrahedron Asymmetry, 2005 , vol. 16, # 19 p. 3283 - 3290
反应条件
Multi-step reaction with 2 steps 1: 1) Propionsaeure, 2a) conc. HCl, 2b) H2O/methanol/KOH / 1) 140-150 deg C, 2a) 110 deg C, 2b) reflux, 2h2: 1) NaHCO3, KI, I2, 2) DBU / 1) H2O, 12 h, 2) benzene, 70 80 deg C, 3 h
参考文献
Guenther, Hans Juergen; Guntrum, Eberhard; Jaeger, Volker Liebigs Annalen der Chemie, 1984 , # 1 p. 15 - 30
