2-(氯羰基)苯甲酸甲酯合成路线 （共 40 条）
反应条件
1: 16 h / Reflux 2: sodium tetrahydroborate / methanol / 0 - 20 °C View Scheme
参考文献
Kachkovskyi, Georgiy O.; Kolodiazhnyi, Oleg I.
Phosphorus, Sulfur and Silicon and the Related Elements, 2010 , vol. 185, # 12 p. 2441 - 2448
反应条件
thionyl chloride; N,N-dimethyl-formamide in toluene
T=60°C; 1 h;
参考文献
INCOZEN THERAPEUTICS PVT. LTD.; RHIZEN PHARMACEUTICALS SA; MUTHUPPALANIAPPAN, Meyyappan; BHAVAR, Prashnant, Kashinath; VISWANADHA, Srikant; VAKKALANKA, Swaroop, Kumar, V.S.; MERIKAPUDI, Gayatri, Swaroop
Patent: WO2011/138665 A1, 2011 ;
Location in patent: Page/Page column 60 ;
WO 2011/138665 A1
反应条件
thionyl chloride; thionyl chloride
2.) 50 deg C; Multistep reaction;
参考文献
Babin, P.; Dunogues, J.
Tetrahedron Letters, 1983 , vol. 24, # 30 p. 3071 - 3074
参考文献
Meyer,H.
Monatshefte fuer Chemie, 1901 , vol. 22, p. 578
反应条件
in diethyl ether
room temp., 2-4 h; column chromay. (silica gel, CH2Cl2), crystn. (CH2Cl2/n-hexane); elem. anal.;
参考文献
El-Hinnawi, Mahmoud A.; Al-Ajlouni, Ahmad M.; AbuNasser, Jamilah S.; Powell, Anne K.; Vahrenkamp, H.
Journal of Organometallic Chemistry, 1989 , vol. 359, p. 79 - 86
参考文献
Nagel; Abelsdorff
Wiss. Veroeff. Siemens, vol. 5, p. 206
Chem. Zentralbl., 1927 , vol. 98, # I p. 78
反应条件
Yield given. Multistep reaction;
参考文献
Tanno; Terashima
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 3 p. 821 - 836
反应条件
1: (i) Et2O, (ii) KOH, EtOH
2: (i) HCO2Et, Et3N, Et2O, (ii) aq. NH3
3: aq. NaOH, Br2
View Scheme
参考文献
Bettembourg,M.-C.; Brunesseaux,Y.
Bulletin de la Societe Chimique de France, 1963 , p. 2449 - 2451
反应条件
1: 75 percent / Triethylamine / CHCl3 / 3 h / Heating
2: 85 percent / 4percent aq. NaOH / ethanol / Heating
3: 28 percent / POCl3, H2O / 5 h / Heating
View Scheme
参考文献
Daidone, Giuseppe; Plescia, Salvatore
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 689 - 690
反应条件
1.1: pyridine / dichloromethane / 0 °C / |Inert atmosphere
1.2: 0 - 20 °C / |Inert atmosphere
2.1: dichloro bis(acetonitrile) palladium(II); p-benozquinone / tert-butyl alcohol; acetone / 20 °C / |Inert atmosphere
View Scheme
参考文献
Dong, Jia Jia; Fananas-Mastral, Martin; Alsters, Paul L.; Browne, Wesley R.; Feringa, Ben L.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 21 p. 5561 - 5565
Angew. Chem., 2013 , vol. 125, # 21 p. 5671 - 5675,5
