1.1: POCl3; Et3N / diethyl ether / 1.25 h / -5 - 20 °C 2.1: Et3N / diethyl ether / -20 - 20 °C 3.1: 92 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / -50 - 20 °C 4.1: n-BuLi / tetrahydrofuran; hexane / 0.08 h / -50 °C 4.2: 91 percent / H2O / tetrahydrofuran; hexane / -50 °C 5.1: 85 percent / aq. H2SO4 / benzene / 4 h / Heating View Scheme

1.1: POCl3; Et3N / diethyl ether / 1.25 h / -5 - 20 °C 2.1: Et3N / diethyl ether / -20 - 20 °C 3.1: 92 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / -50 - 20 °C 4.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -50 °C 4.2: 86 percent / tetrahydrofuran; hexane / 1 h / -50 - 20 °C 5.1: 70 percent / aq. H2SO4 / benzene / 4 h / Heating View Scheme

1.1: POCl3; Et3N / diethyl ether / 1.25 h / -5 - 20 °C 2.1: Et3N / diethyl ether / -20 - 20 °C 3.1: 92 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / -50 - 20 °C 4.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -50 °C 4.2: 94 percent / tetrahydrofuran; hexane / 1 h / -50 - 20 °C 5.1: 70 percent / aq. H2SO4 / benzene / 4 h / Heating View Scheme

1.1: POCl3; Et3N / diethyl ether / 1.25 h / -5 - 20 °C 2.1: Et3N / diethyl ether / -20 - 20 °C 3.1: 92 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / -50 - 20 °C 4.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -50 °C 4.2: 74 percent / tetrahydrofuran; hexane / 1 h / -50 - 20 °C 5.1: 61 percent / aq. H2SO4 / benzene / 4 h / Heating View Scheme

1.1: POCl3; Et3N / diethyl ether / 1.25 h / -5 - 20 °C 2.1: Et3N / diethyl ether / -20 - 20 °C 3.1: 92 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / -50 - 20 °C 4.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -50 °C 4.2: 75 percent / tetrahydrofuran; hexane / 1 h / -50 - 20 °C 5.1: 67 percent / aq. H2SO4 / benzene / 4 h / Heating View Scheme

1: toluene / 8 h / 80 °C / |Molecular sieve; |Inert atmosphere 2: palladium diacetate; tetrabutylammomium bromide; oxygen / dimethyl sulfoxide / 24 h / 30 °C / 760.05 Torr / |Glovebox; |Molecular sieve View Scheme

triethylamine in dichloromethane T=20°C;

[{(η5-C5Me5)RhCl}2(μ-Cl)2]; copper (II) acetate monohydrate in methanol T=100°C; 4 h;

1.1: POCl3; Et3N / diethyl ether / 1.25 h / -5 - 20 °C 2.1: Et3N / diethyl ether / -20 - 20 °C 3.1: 92 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / -50 - 20 °C 4.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -50 °C 4.2: 98 percent / tetrahydrofuran; hexane / 1 h / -50 - 20 °C 5.1: 84 percent / aq. H2SO4 / benzene / 4 h / Heating View Scheme

Multi-step reaction with 3 steps 1: NaH / diethyl ether / 0 - 20 °C2: xylene / 14 h / Heating3: 82 percent / 6N NaOH / ethanol / 40 h / 20 °C