6-甲氧基-2-(4-苯甲氧基)苯并噻吩合成路线 （共 35 条）
反应条件
1: diethyl ether; benzene 2: KHSO4 / 195 - 200 °C 3: ethanolic KOH / 200 - 210 °C View Scheme
参考文献
Proceedings of the Royal Society of London, Series B: Biological Sciences, , vol. 127, p. 140,153 Anm. 154
Proceedings of the Royal Society of London, , vol. 132, p. 83,91
反应条件
1: diethyl ether; benzene 2: KHSO4 / 195 - 200 °C 3: ethanolic KOH / 200 - 210 °C 4: acetone; palladium/charcoal / Hydrogenation View Scheme
参考文献
Proceedings of the Royal Society of London, Series B: Biological Sciences, , vol. 127, p. 140,153 Anm. 154
Proceedings of the Royal Society of London, , vol. 132, p. 83,91
反应条件
1: diethyl ether / 2 h / Heating 2: BBr3 / CH2Cl2 / 7 h / -5 - 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 18 p. 4659 - 4663
反应条件
1: diethyl ether; benzene 2: KHSO4 / 195 - 200 °C 3: ethanolic KOH / 200 - 210 °C 4: acetone; palladium/charcoal / Hydrogenation 5: aqueous NaOH View Scheme
参考文献
Dodds et al.
Proceedings of the Royal Society of London, Series B: Biological Sciences, 1939 , vol. 127, p. 140,153 Anm. 154
Proceedings of the Royal Society of London, 1944 , vol. 132, p. 83,91
反应条件
1: diethyl ether; benzene 2: KHSO4 / 195 - 200 °C 3: ethanolic KOH / 200 - 210 °C View Scheme
参考文献
Proceedings of the Royal Society of London, Series B: Biological Sciences, , vol. 127, p. 140,153 Anm. 154
Proceedings of the Royal Society of London, , vol. 132, p. 83,91
反应条件
18-crown-6 ether; potassium tert-butylate in tetrahydrofuran
T=20°C; 0.5 h; Inert atmosphere;
参考文献
Waibel, Michael; De Angelis, Meri; Stossi, Fabio; Kieser, Karen J.; Carlson, Kathryn E.; Katzenellenbogen, Benita S.; Katzenellenbogen, John A.
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 9 p. 3412 - 3424
反应条件
sodium hydroxide; ethanol
参考文献
Squibb and Sons
Patent: US2252696 , 1939 ;
反应条件
pyridine; thionyl chloride; benzene
durch Behandeln des hergestellten Saeurechlorids mit Anisol und SnCl4 in Benzol;
参考文献
Wilds; Biggerstaff
Journal of the American Chemical Society, 1945 , vol. 67, p. 789,791
反应条件
1: 67 percent / AlCl3 / 1,2-dichloro-ethane / 2 h / Heating
2: 78 percent / potassium tert-butanolate / diethyl ether / Heating
View Scheme
参考文献
Lubczyk, Veronika; Bachmann, Helmut; Gust, Ronald
Journal of Medicinal Chemistry, 2003 , vol. 46, # 8 p. 1484 - 1491
反应条件
1: 67 percent / AlCl3 / 1,2-dichloro-ethane / 2 h / Heating
2: 78 percent / potassium tert-butanolate / diethyl ether / Heating
View Scheme
参考文献
Lubczyk, Veronika; Bachmann, Helmut; Gust, Ronald
Journal of Medicinal Chemistry, 2003 , vol. 46, # 8 p. 1484 - 1491
