2-氨基-3-甲基苯甲酸合成路线 （共 84 条）
反应条件
1: 2-amino-3-methyl benzoic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran T=40°C; 3 h; 2: methylamine in tetrahydrofuran T=20°C; 1 h;
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1757594 A1, 2007 ;
Location in patent: Page/Page column 50 ;
EP 1757594 A1
反应条件
1: thionyl chloride / Reflux 2: dichloromethane View Scheme
参考文献
Feng, Qi; Liu, Zhi-Li; Xiong, Li-Xia; Wang, Ming-Zhong; Li, Yong-Qiang; Li, Zheng-Ming
Journal of Agricultural and Food Chemistry, 2010 , vol. 58, # 23 p. 12327 - 12336
反应条件
1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.67 h / 100 °C 2.1: thionyl chloride / 3 h / |Reflux 2.2: 20 °C / |Cooling with ice View Scheme
参考文献
Zhao, Yu; Xiong, Li-Xia; Xu, Li-Ping; Wang, Hongxue; Xu, Han; Li, Hua-Bin; Tong, Jun; Li, Zheng-Ming
Research on Chemical Intermediates, 2013 , vol. 39, # 7 p. 3071 - 3088
反应条件
1: With 1,1'-carbonyldiimidazole in N,N-dimethyl-formamide T=70°C; 1 h; Inert atmosphere; 2: With ammonium hydroxide in N,N-dimethyl-formamide
参考文献
Nathubhai, Amit; Patterson, Richard; Woodman, Timothy J.; Sharp, Harriet E. C.; Chui, Miranda T. Y.; Chung, Hugo H. K.; Lau, Stephanie W. S.; Zheng, Jun; Lloyd, Matthew D.; Thompson, Andrew S.; Threadgill, Michael D.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 17 p. 6089 - 6099
反应条件
DIEA; benzotriazol-1-ol in N,N-dimethyl-formamide
参考文献
AMBIT BIOSCIENCES CORP.
Patent: US2012/53176 A1, 2012 ;
US 20120053176 A1
反应条件
sulfuric acid; sodium nitrite in water; ethyl acetate
参考文献
Agrevo UK Limited
Patent: US6034121 A1, 2000 ;
参考文献
Findeklee
Chemische Berichte, 1905 , vol. 38, p. 3555
反应条件
in 1,4-dioxane 6.5 h; Reflux;
参考文献
Ou, Junjun; Zhu, Xiaokun; Wang, Lei; Xu, Chuan; Liu, Feng; Ren, Long; Xu, Xibao; Wang, Yi; Rui, Changhui; Liu, Shangzhong
Journal of Agricultural and Food Chemistry, 2012 , vol. 60, # 44 p. 10942 - 10951
反应条件
bis(trichloromethyl) carbonate; N-ethyl-N,N-diisopropylamine in tetrahydrofuran; dichloromethane T=20°C; 16.5 h;
参考文献
3-DIMENSIONAL PHARMACEUTICALS, INC.
Patent: WO2003/99805 A1, 2003 ;
Location in patent: Page 403 ;
反应条件
in 1,4-dioxane; benzene Ambient temperature;
参考文献
Sircar, Jagadish C.; Capiris, Thomas; Kesten, Stephen J.; Herzig, David J.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 735 - 742
