1.1: potassium carbonate / acetonitrile / 10 h / 25 - 35 °C / Reflux 2.1: phosphorus tribromide / dichloromethane / 2 h / 0 - 10 °C 3.1: toluene / 2 h / 85 - 90 °C 4.1: sodium hydroxide; water / ethanol / 72 h / Reflux 4.2: pH 1 - 1.2 4.3: 35 h / 155 °C 5.1: (S)-1-phenyl-ethylamine / ethyl acetate / 4 h / 10 °C 5.2: pH 1 - 1.2 6.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 2 h / 20 °C 6.2: 5 °C 7.1: triphenylphosphine; N-bromosuccinmide / dichloromethane / 4 h / 5 - 10 °C View Scheme

1.1: potassium carbonate / acetonitrile / 10 h / 25 - 35 °C / Reflux 2.1: phosphorus tribromide / dichloromethane / 2 h / 0 - 10 °C 3.1: toluene / 2 h / 85 - 90 °C 4.1: sodium hydroxide; water / ethanol / 72 h / Reflux 4.2: pH 1 - 1.2 4.3: 35 h / 155 °C 5.1: (S)-1-phenyl-ethylamine / ethyl acetate / 4 h / 10 °C 5.2: pH 1 - 1.2 6.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 2 h / 20 °C 6.2: 5 °C View Scheme

1.1: potassium carbonate / acetonitrile / 10 h / 25 - 35 °C / Reflux 2.1: phosphorus tribromide / dichloromethane / 2 h / 0 - 10 °C 3.1: toluene / 2 h / 85 - 90 °C 4.1: sodium hydroxide; water / ethanol / 72 h / Reflux 4.2: pH 1 - 1.2 4.3: 35 h / 155 °C 5.1: (S)-1-phenyl-ethylamine / ethyl acetate / 4 h / 10 °C 5.2: pH 1 - 1.2 View Scheme

1: (KO3S)2NO, aq. KH2PO4 2: methanol / Heating 3: KOAc / methanol / Heating View Scheme

1: K2CO3; acetone 2: 230 °C View Scheme

potassium dihydrogenphosphate; Fremy’s salt

1: potassium carbonate / acetone / 4 h / Reflux; Inert atmosphere 2: phosphorus tribromide / dichloromethane / 1.33 h / -5 - 20 °C View Scheme

RbF in acetonitrile T=80°C; 0.5 h;

in toluene Acetylation; 72 h; Heating; Title compound not separated from byproducts;

1: K2CO3; acetone 2: 230 °C 3: K2CO3 4: KMnO4; aqueous NaOH View Scheme