2-(氨基甲基)喹唑啉-4(3H)-酮合成路线 （共 6 条）
反应条件
triphenylphosphine in tetrahydrofuran; water
T=20°C; 19 h; Inert atmosphere;
参考文献
Lindgren, Anders E.G.; Karlberg, Tobias; Ekblad, Torun; Spjut, Sara; Thorsell, Ann-Gerd; Andersson, C. David; Nhan, Ton Tong; Hellsten, Victor; Weigelt, Johan; Linusson, Anna; Schueler, Herwig; Elofsson, Mikael
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9556 - 9568
反应条件
1: pyridine / N,N-dimethyl-formamide
2: potassium carbonate; urea hydrogen peroxide addition compound / acetone; water
3: hydrogen bromide / water
4: triphenylphosphine; carbon tetrabromide / dichloromethane / 22 h / 0 - 20 °C
5: sodium azide / acetone; water / 0.33 h / 70 °C / |Microwave irradiation
6: triphenylphosphine / water; tetrahydrofuran / 19 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Lindgren, Anders E.G.; Karlberg, Tobias; Ekblad, Torun; Spjut, Sara; Thorsell, Ann-Gerd; Andersson, C. David; Nhan, Ton Tong; Hellsten, Victor; Weigelt, Johan; Linusson, Anna; Schueler, Herwig; Elofsson, Mikael
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9556 - 9568
反应条件
1: potassium carbonate; urea hydrogen peroxide addition compound / acetone; water
2: hydrogen bromide / water
3: triphenylphosphine; carbon tetrabromide / dichloromethane / 22 h / 0 - 20 °C
4: sodium azide / acetone; water / 0.33 h / 70 °C / |Microwave irradiation
5: triphenylphosphine / water; tetrahydrofuran / 19 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Lindgren, Anders E.G.; Karlberg, Tobias; Ekblad, Torun; Spjut, Sara; Thorsell, Ann-Gerd; Andersson, C. David; Nhan, Ton Tong; Hellsten, Victor; Weigelt, Johan; Linusson, Anna; Schueler, Herwig; Elofsson, Mikael
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9556 - 9568
反应条件
1: hydrogen bromide / water
2: triphenylphosphine; carbon tetrabromide / dichloromethane / 22 h / 0 - 20 °C
3: sodium azide / acetone; water / 0.33 h / 70 °C / |Microwave irradiation
4: triphenylphosphine / water; tetrahydrofuran / 19 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Lindgren, Anders E.G.; Karlberg, Tobias; Ekblad, Torun; Spjut, Sara; Thorsell, Ann-Gerd; Andersson, C. David; Nhan, Ton Tong; Hellsten, Victor; Weigelt, Johan; Linusson, Anna; Schueler, Herwig; Elofsson, Mikael
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9556 - 9568
反应条件
1: triphenylphosphine; carbon tetrabromide / dichloromethane / 22 h / 0 - 20 °C
2: sodium azide / acetone; water / 0.33 h / 70 °C / |Microwave irradiation
3: triphenylphosphine / water; tetrahydrofuran / 19 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Lindgren, Anders E.G.; Karlberg, Tobias; Ekblad, Torun; Spjut, Sara; Thorsell, Ann-Gerd; Andersson, C. David; Nhan, Ton Tong; Hellsten, Victor; Weigelt, Johan; Linusson, Anna; Schueler, Herwig; Elofsson, Mikael
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9556 - 9568
反应条件
1: sodium azide / acetone; water / 0.33 h / 70 °C / |Microwave irradiation
2: triphenylphosphine / water; tetrahydrofuran / 19 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Lindgren, Anders E.G.; Karlberg, Tobias; Ekblad, Torun; Spjut, Sara; Thorsell, Ann-Gerd; Andersson, C. David; Nhan, Ton Tong; Hellsten, Victor; Weigelt, Johan; Linusson, Anna; Schueler, Herwig; Elofsson, Mikael
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9556 - 9568
