4-氯-6-硝基-2-(1-哌嗪)喹啉合成路线 （共 7 条）
反应条件
sulfuric acid in tetrahydrofuran
T=80°C; 3 h;
参考文献
Se Lee, Byoung; Chu, Soyoung; Lee, Bon-Su; Yoon Chi, Dae; Song, Yun Seon; Jin, Changbae
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 5 p. 811 - 815
反应条件
1: polyphosphoric acid / 2.5 h / 120 °C
2: phosphorus oxychloride / 2.5 h / 80 °C
3: 0 °C
View Scheme
参考文献
Byung, Seok Moon; Byoung, Se Lee; Dae, Yoon Chi
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 16 p. 4952 - 4959
反应条件
1: dimethylformamide / 3 h / 60 °C
2: aq. H2SO4 / tetrahydrofuran / 3 h / 80 °C
View Scheme
参考文献
Se Lee, Byoung; Chu, Soyoung; Lee, Bon-Su; Yoon Chi, Dae; Song, Yun Seon; Jin, Changbae
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 5 p. 811 - 815
反应条件
1: 74 percent / 12 h / 150 °C
2: 36 percent / polyphosphoric acid / 3 h / 120 °C
3: 61 percent / POCl3 / 6 h / Heating
4: dimethylformamide / 3 h / 60 °C
5: aq. H2SO4 / tetrahydrofuran / 3 h / 80 °C
View Scheme
参考文献
Se Lee, Byoung; Chu, Soyoung; Lee, Bon-Su; Yoon Chi, Dae; Song, Yun Seon; Jin, Changbae
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 5 p. 811 - 815
反应条件
1: 61 percent / POCl3 / 6 h / Heating
2: dimethylformamide / 3 h / 60 °C
3: aq. H2SO4 / tetrahydrofuran / 3 h / 80 °C
View Scheme
参考文献
Se Lee, Byoung; Chu, Soyoung; Lee, Bon-Su; Yoon Chi, Dae; Song, Yun Seon; Jin, Changbae
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 5 p. 811 - 815
反应条件
1: phosphorus oxychloride / 2.5 h / 80 °C
2: 0 °C
View Scheme
参考文献
Byung, Seok Moon; Byoung, Se Lee; Dae, Yoon Chi
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 16 p. 4952 - 4959
参考文献
Byung, Seok Moon; Byoung, Se Lee; Dae, Yoon Chi
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 16 p. 4952 - 4959
