2-(氯甲基)-3-甲基-吡啶合成路线 （共 5 条）
反应条件
potassium hydroxide; chlorine in cyclohexane; water
参考文献
Rutgerswerke Aktiengesellschaft
Patent: US4719298 A1, 1988 ;
参考文献
Hoffmann-La Roche Inc.
Patent: US4634710 A1, 1987 ;
反应条件
thionyl chloride in dichloromethane
T=25°C; 2 h;
参考文献
Weidmann, Klaus; Herling, Andreas W.; Lang, Hans-Jochen; Scheunemann, Karl-Heinz; Rippel, Robert; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 3 p. 438 - 450
反应条件
diisopropylamine; trichloromethyl chloroformate in dichloromethane
T=-40 - 20°C;
参考文献
Narendar; Gangadasu; Ramesh, Ch.; Raju, B. China; Rao, V. Jayathirtha
Synthetic Communications, 2004 , vol. 34, # 6 p. 1097 - 1103
反应条件
1: 2N aq. NaOH / methanol / 2 h / 25 °C
2: SOCl2 / CH2Cl2 / 2 h / 25 °C
View Scheme
参考文献
Weidmann, Klaus; Herling, Andreas W.; Lang, Hans-Jochen; Scheunemann, Karl-Heinz; Rippel, Robert; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 3 p. 438 - 450
