3-(3-甲氧基苯基)吡啶合成路线 （共 28 条）
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water 4 h; Heating / reflux;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2004/48334 A1, 2004 ;
Location in patent: Page 102-103 ;
WO 2004/048334 A1
反应条件
sodium carbonate; bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran; water 4 h; Heating / reflux;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2004/48334 A1, 2004 ;
Location in patent: Page 101-102 ;
WO 2004/048334 A1
反应条件
copper(l) iodide; C37H51ClFeNPPd; cesium fluoride in N,N-dimethyl-formamide T=80°C; Stille Cross Coupling; 12 h; Inert atmosphere;
参考文献
Ma, Gaizhi; Leng, Yuting; Wu, Yusheng; Wu, Yangjie
Tetrahedron, 2013 , vol. 69, # 2 p. 902 - 909
反应条件
NiCl2((PPh3)P)2 in tetrahydrofuran 24 h; Ambient temperature;
参考文献
Thorberg; Gawell; Csoregh; Nilsson
Tetrahedron, 1985 , vol. 41, # 1 p. 129 - 139
反应条件
1: dihydroxy-(3-methoxyphenyl)borane in toluene T=20 - 65°C; dehydrationvacuum; 2: 3-(N,N-diethylcarbamoyloxy)-pyridine With potassium phosphate; NiCl2(PCy3)2; PCy3∙HBF4 in o-xylene T=150°C; Suzuki-Miyaura coupling; 5 h; Inert atmosphere;
参考文献
Antoft-Finch, Aurora; Blackburn, Tom; Snieckus, Victor
Journal of the American Chemical Society, 2009 , vol. 131, # 49 p. 17750 - 17752
反应条件
potassium carbonate; cyclopallated ferrocenylimine c in water; N,N-dimethyl-formamide T=110°C; Suzuki cross-coupling reaction; 6 h;
参考文献
Zhang, Jinli; Zhao, Liang; Song, Maoping; Mak, Thomas C.W.; Wu, Yangjie
Journal of Organometallic Chemistry, 2006 , vol. 691, # 6 p. 1301 - 1306
反应条件
NiClCpIMes in tetrahydrofuran; diethyl ether T=20°C; Grignard cross-coupling reaction; 4 h;
参考文献
Macklin, Todd K.; Snieckus, Victor
Organic Letters, 2005 , vol. 7, # 13 p. 2519 - 2522
反应条件
sodium carbonate; tetrakis (triphenylphosphine) palladium (0) in ethanol; water
参考文献
Pfizer Inc.
Patent: US2002/177591 A1, 2002 ;
反应条件
potassium phosphate; palladium dichloride; S-2,2',6,6'-tetramethoxy-4,4'-bis(diphenylphosphino)-3,3'-bipyridine in butan-1-ol T=100°C; Suzuki coupling; 6 h; Inert atmosphere;
参考文献
Fu, Xing-Li; Wu, Lei-Lei; Fu, Hai-Yan; Chen, Hua; Li, Rui-Xiang
European Journal of Organic Chemistry, 2009 , # 13 p. 2051 - 2054
反应条件
morpholine; C31H45Cl2N3OPd; caesium carbonate in water T=110°C; Suzuki-Miyaura Coupling; 12 h; Inert atmosphere;
参考文献
Wang, Zhan-Yong; Ma, Qin-Na; Li, Ren-Hao; Shao, Li-Xiong
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 45 p. 7899 - 7906
