5-氨基-3-苯基异噁唑合成路线 （共 33 条）
反应条件
1: aqueous alcohol 2: diluted NaOH-solution; hydroxylamine View Scheme
参考文献
Obregia
Justus Liebigs Annalen der Chemie, 1891 , vol. 266, p. 329
反应条件
hydrogenchloride; ethanol; hydroxylamine; sodium carbonate
参考文献
Cusmano et al.
Gazzetta Chimica Italiana, 1952 , vol. 82, p. 98,104, 105
反应条件
1: With sodium hydride 2: With hydroxylamine
参考文献
Volochnyuk, Dmitriy M.; Ryabukhin, Sergey V.; Plaskon, Andrey S.; Dmytriv, Yuri V.; Grygorenko, Oleksandr O.; Mykhailiuk, Pavel K.; Krotko, Dmitriy G.; Pushechnikov, Alexei; Tolmachev, Andrey A.
Journal of Combinatorial Chemistry, 2010 , vol. 12, # 4 p. 510 - 517
参考文献
Tatee; Narita; Kurashige; Ito; Miyazaki; Yamanaka; Mizugaki; Sakamoto; Fukuda
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 4 p. 1643 - 1655
反应条件
trichlorophosphate
T=55 - 60°C; 20 h;
参考文献
Sakamoto, Takao; Yamanaka, Hiroshi; Shiozawa, Akira; Tanaka, Wataru; Miyazaki, Hiroshi
Chemical & Pharmaceutical Bulletin, 1980 , vol. 28, # 6 p. 1832 - 1835
反应条件
1: Raney nickel; ethanol / Hydrogenation
2: ethanol
View Scheme
参考文献
Shaw; Sugowdz
Journal of the Chemical Society, 1954 , p. 665,668
反应条件
1: 74 percent / pyridine / CHCl3 / 3.5 h / Ambient temperature
2: 71 percent / ethanol / 2 h / Heating
View Scheme
参考文献
Tatee; Kurashige; Shiozawa; Narita; Takei; Ito; Miyazaki; Yamanaka; Mizugaki; Sakamoto
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 4 p. 1634 - 1642
反应条件
1: 72 percent / pyridine / CHCl3 / 2 h / -5 °C
2: 82 percent / ethanol / 8 h / Heating
View Scheme
参考文献
Tatee; Kurashige; Shiozawa; Narita; Takei; Ito; Miyazaki; Yamanaka; Mizugaki; Sakamoto
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 4 p. 1634 - 1642
反应条件
1: 72 percent / pyridine / CHCl3 / 2 h / -5 °C
2: 84 percent / ethanol / 8 h / Heating
View Scheme
参考文献
Tatee; Kurashige; Shiozawa; Narita; Takei; Ito; Miyazaki; Yamanaka; Mizugaki; Sakamoto
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 4 p. 1634 - 1642
反应条件
1: 44 percent / Na2CO3 / CHCl3 / 7 h / Heating
2: 90 percent / ethanol / 30 h / Heating
View Scheme
参考文献
Tatee; Kurashige; Shiozawa; Narita; Takei; Ito; Miyazaki; Yamanaka; Mizugaki; Sakamoto
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 4 p. 1634 - 1642
