1-苄基-1H-1,2,3-噻唑合成路线 （共 26 条）
反应条件
hydrogen; palladium on activated charcoal in 1,4-dioxane T=110°C; P=53200 Torr; 3 h;
参考文献
Iddon, Brian; Nicholas, Martin
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 12 p. 1341 - 1347
反应条件
potassium carbonate in acetone
T=56°C; Reflux;
参考文献
EVOTEC NEUROSCIENCES GMBH
Patent: WO2009/95394 A1, 2009 ;
Location in patent: Page/Page column 68-69 ;
WO 2009/095394 A1
反应条件
1: 2-chloro-ethanol With tetra-(n-butyl)ammonium iodide; potassium iodide in tetrahydrofuran; N,N-dimethyl-formamide
T=80°C; 24 h; polystyrene/1percent divinylbenzene resin; Inert atmosphere;
2: With acetic anhydride; 1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran
T=0 - 20°C; polystyrene/1percent divinylbenzene resin;
3: benzyl azide Further stages;
参考文献
Huang, Zhenzhong; Wang, Ruiling; Sheng, Shouri; Zhou, Ruyi; Cai, Mingzhong
Reactive and Functional Polymers, 2013 , vol. 73, # 1 p. 224 - 227
反应条件
sodium hydroxide; sodium iodide in 1,1-dimethylpropan-1-ol; toluene
参考文献
Ikemoto, Tomomi; Ito, Tatsuya; Tomimatsu, Kiminori; Sawai, Yasuhiro; Nishiyama, Hirohiko; Isogami, Yasushi
Patent: US2003/69419 A1, 2003 ;
反应条件
copper(l) iodide; triethylamine in dimethyl sulfoxide
T=20°C; P=760.051 Torr; 24 h;
参考文献
Wu, Lu-Yong; Xie, Yong-Xin; Chen, Zi-Sheng; Niu, Yan-Ning; Liang, Yong-Min
Synlett, 2009 , # 9 p. 1453 - 1456
反应条件
potassium carbonate; potassium iodide in acetone
Inert atmosphereReflux;
参考文献
Doiron, Jeremie; Soultan, Al Haliffa; Richard, Ryan; Toure, Mamadou Mansour; Picot, Nadia; Richard, Remi; Cuperlovic-Culf, Miroslava; Robichaud, Gilles A.; Touaibia, Mohamed
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 4010 - 4024
反应条件
trimethyl orthoformate
T=120°C; 30 h;
参考文献
Dahl, Russell S.; Finney, Nathaniel S.
Journal of the American Chemical Society, 2004 , vol. 126, # 27 p. 8356 - 8357
反应条件
copper(l) iodide; sodium azide in water; dimethyl sulfoxide
T=80°C; 2 h; Reagent/catalystSolventTime;
参考文献
Kim, Taejung; Song, Jung Ho; Jeong, Kyu Hyuk; Lee, Seokjoon; Ham, Jungyeob
European Journal of Organic Chemistry, 2013 , # 19 p. 3992 - 3996
反应条件
copper(l) iodide; water in triethylamine
T=55°C; 6 h;
参考文献
Gonda, Zsombor; Lrincz, Krisztian; Novak, Zoltan
Tetrahedron Letters, 2010 , vol. 51, # 48 p. 6275 - 6277
反应条件
copper(l) iodide; sodium azide; caesium carbonate; sodium L-ascorbate in N,N-dimethyl-formamide
T=100°C; 0.5 h; Sealed tubeInert atmosphere; Reagent/catalystSolvent;
参考文献
Zhang, Zhongkui; Kuang, Chunxiang
Chinese Journal of Chemistry, 2013 , vol. 31, # 8 p. 1011 - 1014
