6-甲氧基-4-喹啉甲醛合成路线 （共 10 条）
反应条件
selenium(IV) oxide in 1,4-dioxane; water T=85°C; Oxidation; 5 h;
参考文献
Friestad, Gregory K.; Ji, An; Korapala, Chandra Sekhar; Qin, Jun
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 11 p. 4039 - 4043
反应条件
1: 4-bromo-6-methoxyquinoline With n-butyllithium in diethyl ether T=-78°C; 2: N,N-dimethyl-formamide in diethyl ether T=-78°C; 3 h;
参考文献
Tukulula, Matshawandile; Little, Susan; Gut, Jiri; Rosenthal, Philip J.; Wan, Baojie; Franzblau, Scott G.; Chibale, Kelly
European Journal of Medicinal Chemistry, 2012 , vol. 57, p. 259 - 267
反应条件
ferrous chloride tetrahydrate; iodine; 2-methyl-2-iodopropane; trifluoroacetic acid in dimethyl sulfoxide T=85 - 95°C; 10 h; Inert atmosphere;
参考文献
Friestad, Gregory K.; Ji, An; Baltrusaitis, Jonas; Korapala, Chandra Sekhar; Qin, Jun
Journal of Organic Chemistry, 2012 , vol. 77, # 7 p. 3159 - 3180
反应条件
1.1: ZnCl2; FeCl3 / ethanol / 40 - 80 °C 1.2: ethanol / 15 h / 80 °C 1.3: 59 percent / Et3N; 4-dimethylaminopyridine; acetic anhydride / tetrahydrofuran / 48 h / 20 °C 2.1: 51 percent / SeO2 / dioxane; H2O / 15.5 h / 80 - 90 °C View Scheme
参考文献
Tukulula, Matshawandile; Little, Susan; Gut, Jiri; Rosenthal, Philip J.; Wan, Baojie; Franzblau, Scott G.; Chibale, Kelly
European Journal of Medicinal Chemistry, 2012 , vol. 57, p. 259 - 267
反应条件
1.1: Dowtherm™ A / 0.33 h / 250 °C 2.1: phosphorus tribromide / N,N-dimethyl-formamide / 2 h / 20 °C / |Inert atmosphere 3.1: n-butyllithium / diethyl ether / -78 °C 3.2: 3 h / -78 °C View Scheme
参考文献
Tukulula, Matshawandile; Little, Susan; Gut, Jiri; Rosenthal, Philip J.; Wan, Baojie; Franzblau, Scott G.; Chibale, Kelly
European Journal of Medicinal Chemistry, 2012 , vol. 57, p. 259 - 267
反应条件
1.1: phosphorus tribromide / N,N-dimethyl-formamide / 2 h / 20 °C / |Inert atmosphere 2.1: n-butyllithium / diethyl ether / -78 °C 2.2: 3 h / -78 °C View Scheme
参考文献
Tukulula, Matshawandile; Little, Susan; Gut, Jiri; Rosenthal, Philip J.; Wan, Baojie; Franzblau, Scott G.; Chibale, Kelly
European Journal of Medicinal Chemistry, 2012 , vol. 57, p. 259 - 267
反应条件
in water 110 h; Irradiation; Product distribution;
参考文献
Laurie, W. A.; McHale, D.; Saag, K.; Sheridan, J. B.
Tetrahedron, 1988 , vol. 44, # 18 p. 5905 - 5910
反应条件
1.1: n-BuLi; TMEDA / tetrahydrofuran / -78 °C 2.1: HCl / TiCl3 2.2: aq. NaOH View Scheme
参考文献
Exner, Christian; Pfaltz, Andreas; Studer, Martin; Blaser, Hans-Ulrich
Advanced Synthesis and Catalysis, 2003 , vol. 345, # 11 p. 1253 - 1260
反应条件
1.1: n-BuLi; TMEDA / tetrahydrofuran / -78 °C 2.1: HCl / TiCl3 2.2: aq. NaOH View Scheme
参考文献
Exner, Christian; Pfaltz, Andreas; Studer, Martin; Blaser, Hans-Ulrich
Advanced Synthesis and Catalysis, 2003 , vol. 345, # 11 p. 1253 - 1260
反应条件
1.1: n-BuLi; TMEDA / tetrahydrofuran / -78 °C 2.1: HCl / TiCl3 2.2: aq. NaOH View Scheme
参考文献
Exner, Christian; Pfaltz, Andreas; Studer, Martin; Blaser, Hans-Ulrich
Advanced Synthesis and Catalysis, 2003 , vol. 345, # 11 p. 1253 - 1260
