3-(2-氯苯基)-5-甲基-4-异噁唑羧酸甲酯合成路线 （共 8 条）
反应条件
(i) Na, MeOH, (ii) /BRN= 2502600/; Multistep reaction;
参考文献
Ramana, P. Venkata; Reddy, A. Ram
Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 3 p. 621 - 627
反应条件
triethylamine T=20°C; 5 h;
参考文献
Perumal, Senthil K.; Adediran; Pratt
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 14 p. 6987 - 6994
反应条件
1: Cl2 2: (i) Na, MeOH, (ii) /BRN= 2502600/ View Scheme
参考文献
Ramana, P. Venkata; Reddy, A. Ram
Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 3 p. 621 - 627
反应条件
1.1: hydroxylammonium sulfate / methanol / 0.5 h 1.2: 0.5 h / pH 8 - 9 / Reflux 2.1: chlorine / methanol / 0 - 5 °C 3.1: sodium hydroxide / methanol / 0.5 h / 0 - 5 °C / pH 10 3.2: 2 h / 0 - 20 °C / pH 9 View Scheme
参考文献
Ramana, P. Venkata; Reddy, A. Ram
Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 3 p. 621 - 627
反应条件
1: aq. KOH / ethanol 2: SOCl2 3: aq. NaOH, isobutyl methyl ketone View Scheme
参考文献
Doyle,F.P. et al.
Journal of the Chemical Society, 1963 , p. 5838 - 5845
反应条件
1: aq. KOH / ethanol 2: SOCl2 View Scheme
参考文献
Journal of the Chemical Society, , p. 5838 - 5845
反应条件
potassium hydroxide in ethanol
参考文献
Ramana, P. Venkata; Reddy, A. Ram
Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 3 p. 621 - 627
反应条件
lithium aluminium tetrahydride in diethyl ether
T=40°C; 1 h;
参考文献
Roy, Amrendra K.; Batra, Sanjay
Synthesis, 2003 , # 9 p. 1347 - 1356
