2,4-二氧代-3-氮杂螺[5.5]十一烷-1,5-二甲腈合成路线 （共 11 条）
反应条件
1: aq. H2SO4 2: aq. H2SO4 View Scheme
参考文献
Handley,G.J. et al.
Australian Journal of Chemistry, 1960 , vol. 13, p. 129 - 144
反应条件
1: acetic acid, HCl, H2O / 84 h / Heating 2: acetic anhydride / 4 h / Heating View Scheme
参考文献
Badger; Schwartz; Picker; Dorman; Bradley; Cheeseman; DiMartino; Hanna; Mirabelli
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 2963 - 2970
反应条件
1: aq. H2SO4 2: aq. H2SO4 3: LiAlH4 / diethyl ether View Scheme
参考文献
Handley,G.J. et al.
Australian Journal of Chemistry, 1960 , vol. 13, p. 129 - 144
参考文献
Australian Journal of Chemistry, , vol. 13, p. 129 - 144
参考文献
Journal of the Chemical Society, , vol. 103, p. 1575
Journal of the Chemical Society, , vol. 123, p. 63
反应条件
ammonia in methanol; water
T=-5 - 25°C; 48 h; Product distribution / selectivity;
参考文献
NHWA Pharma Corporation
Patent: US2009/99362 A1, 2009 ;
Location in patent: Page/Page column 3-4 ;
反应条件
triethylamine in methanol
T=25 - 30°C; 8 h; Product distribution / selectivity;
参考文献
NHWA Pharma Corporation
Patent: US2009/99362 A1, 2009 ;
Location in patent: Page/Page column 3 ;
参考文献
Thole; Thorpe
Journal of the Chemical Society, 1911 , vol. 99, p. 440
Full Text Show Details
Thorpe; Wood
Journal of the Chemical Society, 1913 , vol. 103, p. 1575
Journal of the Chemical Society, 1923 , vol. 123, p. 63
参考文献
Birch; Kon; Norris
Journal of the Chemical Society, 1923 , vol. 123, p. 1365
反应条件
sulfuric acid; water
T=65 - 85°C; 2.5 - 3.5 h; Product distribution / selectivity;
参考文献
NHWA Pharma Corporation
Patent: US2009/99362 A1, 2009 ;
Location in patent: Page/Page column 2-4 ;
