4-(4-氯苯基)-2-甲硫基嘧啶合成路线 (共 3 条)
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water
T=90°C; 20 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2004/762 A2, 2003 ;
Location in patent: Page 38 ;
WO 2004/000762 A2
反应条件
in aqueous potassium hydroxide
参考文献
Kois, Adam; MacFarlane, Karen J.; Satoh, Yoshitaka; Bhagwat, Shripad S.; Parnes, Jason S.; Palanki, Moorthy S.S.; Erdman, Paul E.
Patent: US2003/203926 A1, 2003 ;
US 20030203926 A1
反应条件
oxone in water; acetone
参考文献
ACTELION PHARMACEUTICALS LTD; AISSAOUI, Hamed; BOSS, Christoph; CIANA, Claire-Lise; SIEGRIST, Romain
Patent: WO2014/72903 A1, 2014 ;
Location in patent: Page/Page column 42-43 ;