2,2’-脱水-L-胸腺嘧啶脱氧核苷合成路线 （共 10 条）
反应条件
1: With hydrogen; 5 palladium on aluminium in water
T=80°C; 1 h;
2: in water
参考文献
Mitsui Chemicals, Inc.
Patent: EP1348712 A1, 2003 ;
Location in patent: Page/Page column 18 ;
反应条件
carbonic acid diphenyl ester; sodium hydrogencarbonate in N,N-dimethyl-formamide
T=150°C; 1 h;
参考文献
Shi, Junxing; Du, Jinfa; Ma, Tianwei; Pankiewicz, Krzysztof W.; Patterson, Steven E.; Tharnish, Phillip M.; McBrayer, Tamara R.; Stuyver, Lieven J.; Otto, Michael J.; Chu, Chung K.; Schinazi, Raymond F.; Watanabe, Kyoichi A.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 5 p. 1641 - 1652
反应条件
hydrogen; 5 alumina-supported palladium in water
T=25 - 75°C; 0.0833333 - 1.08333 h; Product distribution / selectivity;
参考文献
Cercus, Jacques; Foulkes, Michael; Heinz, Thomas; Niederer, Daniel; Schmitz, Beat
Patent: US2009/18325 A1, 2009 ;
Location in patent: Page/Page column 2-3; 5 ;
反应条件
1: 96 percent / sodium methoxide / methanol / 20 °C
2: 91 percent / diphenyl carbonate; NaHCO3 / dimethylformamide / 1 h / 150 °C
View Scheme
参考文献
Shi, Junxing; Du, Jinfa; Ma, Tianwei; Pankiewicz, Krzysztof W.; Patterson, Steven E.; Tharnish, Phillip M.; McBrayer, Tamara R.; Stuyver, Lieven J.; Otto, Michael J.; Chu, Chung K.; Schinazi, Raymond F.; Watanabe, Kyoichi A.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 5 p. 1641 - 1652
反应条件
1.1: 1,1,1,3,3,3-hexamethyldisilazane / 3 h / Heating
1.2: 73 percent / trimethylsilyl trifluoromethanesulfonate / acetonitrile / 20 °C
2.1: 96 percent / sodium methoxide / methanol / 20 °C
3.1: 91 percent / diphenyl carbonate; NaHCO3 / dimethylformamide / 1 h / 150 °C
View Scheme
参考文献
Shi, Junxing; Du, Jinfa; Ma, Tianwei; Pankiewicz, Krzysztof W.; Patterson, Steven E.; Tharnish, Phillip M.; McBrayer, Tamara R.; Stuyver, Lieven J.; Otto, Michael J.; Chu, Chung K.; Schinazi, Raymond F.; Watanabe, Kyoichi A.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 5 p. 1641 - 1652
反应条件
1.1: 99 percent / acetic acid; sulfuric acid / 16 h / 20 °C
2.1: 1,1,1,3,3,3-hexamethyldisilazane / 3 h / Heating
2.2: 73 percent / trimethylsilyl trifluoromethanesulfonate / acetonitrile / 20 °C
3.1: 96 percent / sodium methoxide / methanol / 20 °C
4.1: 91 percent / diphenyl carbonate; NaHCO3 / dimethylformamide / 1 h / 150 °C
View Scheme
参考文献
Shi, Junxing; Du, Jinfa; Ma, Tianwei; Pankiewicz, Krzysztof W.; Patterson, Steven E.; Tharnish, Phillip M.; McBrayer, Tamara R.; Stuyver, Lieven J.; Otto, Michael J.; Chu, Chung K.; Schinazi, Raymond F.; Watanabe, Kyoichi A.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 5 p. 1641 - 1652
反应条件
1.1: 1,1,1,3,3,3-hexamethyldisilazane / 3 h / Heating
1.2: 73 percent / trimethylsilyl trifluoromethanesulfonate / acetonitrile / 20 °C
2.1: 96 percent / sodium methoxide / methanol / 20 °C
3.1: 91 percent / diphenyl carbonate; NaHCO3 / dimethylformamide / 1 h / 150 °C
View Scheme
参考文献
Shi, Junxing; Du, Jinfa; Ma, Tianwei; Pankiewicz, Krzysztof W.; Patterson, Steven E.; Tharnish, Phillip M.; McBrayer, Tamara R.; Stuyver, Lieven J.; Otto, Michael J.; Chu, Chung K.; Schinazi, Raymond F.; Watanabe, Kyoichi A.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 5 p. 1641 - 1652
反应条件
Product distribution / selectivity;
参考文献
Storer, Richard; Moussa, Adel; Wang, Jingyang; Chaudhuri, Narayan C.; Mathieu, Steven; Stewart, Alistair
Patent: US2005/59632 A1, 2005 ;
Location in patent: Page/Page column 31 ;
反应条件
Product distribution / selectivity;
参考文献
Storer, Richard; Moussa, Adel; Wang, Jingyang; Chaudhuri, Narayan C.; Mathieu, Steven; Stewart, Alistair
Patent: US2005/59632 A1, 2005 ;
Location in patent: Page/Page column 30 ;
反应条件
Product distribution / selectivity;
参考文献
Storer, Richard; Moussa, Adel; Wang, Jingyang; Chaudhuri, Narayan C.; Mathieu, Steven; Stewart, Alistair
Patent: US2005/59632 A1, 2005 ;
Location in patent: Page/Page column 32 ;
