5-溴-2-(2,2,2-三氟乙氧基)嘧啶合成路线 （共 2 条）
反应条件
potassium carbonate in acetonitrile
T=70°C; 12 h;
参考文献
Brewster, William Kirkland; Klittich, Carla Jean Rasmussen; Balko, Terry William; Breaux, Nneka Tuere; Erickson, William Randal; Hunter, James Edward; Lowe, Christian Thomas; Ricks, Michael John; Siddall, Thomas Lyman; Yerkes, Carla Nanette; Zhu, Yuanming
Patent: US2006/89370 A1, 2006 ;
Location in patent: Page/Page column 34-35 ;
反应条件
1: 2,2,2-trifluoroethanol With sodium hydride
T=0 - 20°C; 1.5 h; Inert atmosphere;
2: 2,5-dibromo-pyrimidine in N,N-dimethyl-formamide
T=20°C; 2 h;
参考文献
Nettekoven, Matthias; Norcross, Roger; Polara, Alessandra
Patent: US2012/108609 A1, 2012 ;
Location in patent: Page/Page column 36 ;
US 20120108609 A1
