1,6-己烷二羧酸二甲酯合成路线 （共 12 条）
反应条件
1: 35 °C / Pig Liver Esterase, pH 8.0, phosphate buffer 2: 77 percent / NaAlH2(C2H5)2 / toluene / 3 h / Ambient temperature 3: CH3ONa / toluene / 2 h / 100 °C 4: conc. H2SO4 / toluene; H2O / 2.5 h / Heating 5: NH4OH / toluene / 15 h / Ambient temperature View Scheme
参考文献
Brion; Marie; Mackiewicz; Roui; Buendia
Tetrahedron Letters, 1992 , vol. 33, # 34 p. 4889 - 4892
反应条件
hydrogenchloride; copper(ll) bromide; lithium diisopropyl amide in tetrahydrofuran; hexane
T=-78°C; var. metal salt; Product distribution;
参考文献
Chung, Sung Kee; Dunn, Larson B.
Journal of Organic Chemistry, 1983 , vol. 48, # 7 p. 1125 - 1127
反应条件
sodium methylate in methanol
参考文献
Mock,W.L.; Hartman,M.E.
Journal of Organic Chemistry, 1977 , vol. 42, p. 459 - 465
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C;
参考文献
Kim, In-Hae; Park, Yong-Kyu; Hammock, Bruce D.; Nishi, Kosuke
Journal of Medicinal Chemistry, 2011 , vol. 54, # 6 p. 1752 - 1761
反应条件
1: NaH / diethyl ether / 1 h / 25 °C
2: 24 h / 100 °C
View Scheme
参考文献
Shahidi, Fereidoon; Tidwell, Thomas T.
Canadian Journal of Chemistry, 1982 , vol. 60, p. 1098 - 1100
反应条件
1: 76 percent / NaH / diethyl ether / 1 h / 25 °C
2: 24 h / 100 °C
View Scheme
参考文献
Shahidi, Fereidoon; Tidwell, Thomas T.
Canadian Journal of Chemistry, 1982 , vol. 60, p. 1098 - 1100
反应条件
hydrogenchloride
dimethyl ester of/the/ dextrorotatory trans-hexahydrophthalic acid;
参考文献
Werner; Conrad
Chemische Berichte, 1899 , vol. 32, p. 3052,3502
参考文献
Shahidi, Fereidoon; Tidwell, Thomas T.
Canadian Journal of Chemistry, 1982 , vol. 60, p. 1098 - 1100
反应条件
Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Yedidia, Varda; Leznoff, Clifford C.
Canadian Journal of Chemistry, 1980 , vol. 58, p. 1144 - 1150
反应条件
lithium cyclohexylisopropyl amide; iodine
1.) THF, -78 deg C, 10 min; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Wilkening, David; Mundy, Bradford P.
Synthetic Communications, 1984 , vol. 14, # 3 p. 227 - 238
