1-对茴香基-1-苯基乙烯合成路线 （共 99 条）
反应条件
tris-(dibenzylideneacetone)dipalladium(0); 1,3-bis-(diphenylphosphino)propane; triethylamine in toluene
T=20 - 80°C; Heck Reaction; 24 h; Inert atmosphere;
参考文献
Martin, Sara E. S.; Watson, Donald A.
Journal of the American Chemical Society, 2013 , vol. 135, # 36 p. 13330 - 13333
反应条件
C26H43ClN4O2P2Pd; tetrabutylammomium bromide; potassium carbonate in 1-methyl-pyrrolidin-2-one; toluene
T=200°C; Heck reaction; 18 h; Inert atmosphere;
参考文献
Bolliger, Jeanne L.; Blacque, Olivier; Frech, Christian M.
Chemistry - A European Journal, 2008 , vol. 14, # 26 p. 7969 - 7977
反应条件
1: tris(1,3-divinyl-1,1,3,3-tetramethyldisiloxane)-bis-platinum(0); tri-tert-butyl phosphine / anhydrous xylene; toluene / 0 - 20 °C / Inert atmosphere
2: potassium hydroxide; bis(dibenzylideneacetone)-palladium(0) / methanol / 20 °C / Inert atmosphere
View Scheme
参考文献
Sore, Hannah F.; Boehner, Christine M.; Laraia, Luca; Logoteta, Patrizia; Prestinari, Cora; Scott, Matthew; Williams, Katharine; Galloway, Warren R. J. D.; Spring, David R.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 2 p. 504 - 515
反应条件
1: triethylsilane; trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C
2: water; mercury dichloride; mercury(II) oxide / acetonitrile / 3 h / 70 °C
3: methanol; sodium tetrahydroborate / 1 h / 0 - 5 °C
4: triethylamine / dichloromethane / 0 - 20 °C
5: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 10 h / 20 °C
View Scheme
参考文献
Balasubramaniam, Sivaraman; Kommidi, Harikrishna; Aidhen, Indrapal Singh
Tetrahedron Letters, 2011 , vol. 52, # 21 p. 2683 - 2686
反应条件
1: water; mercury dichloride; mercury(II) oxide / acetonitrile / 3 h / 70 °C
2: methanol; sodium tetrahydroborate / 1 h / 0 - 5 °C
3: triethylamine / dichloromethane / 0 - 20 °C
4: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 10 h / 20 °C
View Scheme
参考文献
Balasubramaniam, Sivaraman; Kommidi, Harikrishna; Aidhen, Indrapal Singh
Tetrahedron Letters, 2011 , vol. 52, # 21 p. 2683 - 2686
反应条件
1: tetrahydrofuran / 2 h / 15 - 20 °C / Inert atmosphere
2: triethylsilane; trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C
3: water; mercury dichloride; mercury(II) oxide / acetonitrile / 3 h / 70 °C
4: methanol; sodium tetrahydroborate / 1 h / 0 - 5 °C
5: triethylamine / dichloromethane / 0 - 20 °C
6: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 10 h / 20 °C
View Scheme
参考文献
Balasubramaniam, Sivaraman; Kommidi, Harikrishna; Aidhen, Indrapal Singh
Tetrahedron Letters, 2011 , vol. 52, # 21 p. 2683 - 2686
反应条件
1: tetrahydrofuran / 2 h / 15 - 20 °C / Inert atmosphere
2: triethylsilane; trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C
3: water; mercury dichloride; mercury(II) oxide / acetonitrile / 3 h / 70 °C
4: methanol; sodium tetrahydroborate / 1 h / 0 - 5 °C
5: triethylamine / dichloromethane / 0 - 20 °C
6: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 10 h / 20 °C
View Scheme
参考文献
Balasubramaniam, Sivaraman; Kommidi, Harikrishna; Aidhen, Indrapal Singh
Tetrahedron Letters, 2011 , vol. 52, # 21 p. 2683 - 2686
反应条件
1: methanol; sodium tetrahydroborate / 1 h / 0 - 5 °C
2: triethylamine / dichloromethane / 0 - 20 °C
3: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 10 h / 20 °C
View Scheme
参考文献
Balasubramaniam, Sivaraman; Kommidi, Harikrishna; Aidhen, Indrapal Singh
Tetrahedron Letters, 2011 , vol. 52, # 21 p. 2683 - 2686
反应条件
1: triethylamine / dichloromethane / 0 - 20 °C
2: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 10 h / 20 °C
View Scheme
参考文献
Balasubramaniam, Sivaraman; Kommidi, Harikrishna; Aidhen, Indrapal Singh
Tetrahedron Letters, 2011 , vol. 52, # 21 p. 2683 - 2686
反应条件
1.1: tetrahydrofuran / 2 h / -30 - -25 °C / Inert atmosphere
1.2: Inert atmosphere
2.1: tetrahydrofuran / 2 h / 15 - 20 °C / Inert atmosphere
3.1: triethylsilane; trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C
4.1: water; mercury dichloride; mercury(II) oxide / acetonitrile / 3 h / 70 °C
5.1: methanol; sodium tetrahydroborate / 1 h / 0 - 5 °C
6.1: triethylamine / dichloromethane / 0 - 20 °C
7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 10 h / 20 °C
View Scheme
参考文献
Balasubramaniam, Sivaraman; Kommidi, Harikrishna; Aidhen, Indrapal Singh
Tetrahedron Letters, 2011 , vol. 52, # 21 p. 2683 - 2686
