1-对茴香基-1-苯基乙烯合成路线 （共 99 条）
反应条件
[hetba]Br; palladium (II) bromide in 1-methyl-pyrrolidin-2-one
T=160°C; decarbonylative Heck olefination; 16 h;
参考文献
Goossen, Lukas J.; Paetzold, Jens
Angewandte Chemie - International Edition, 2004 , vol. 43, # 9 p. 1095 - 1098
反应条件
sodium acetate; tetra-phenylphosphonium bromide; palladium dichloride in N,N-dimethyl-formamide
T=140°C; Arylation; Heck reaction; 15 h;
参考文献
Varma, Rajender S.; Naicker, Kannan P.; Liesen, Per J.
Tetrahedron Letters, 1999 , vol. 40, # 11 p. 2075 - 2078
反应条件
1: 56 percent / tetrahydrofuran / 4.5 h / 20 °C
2: 80 percent / K2CO3 / PdCl2; tri(2-furyl)phosphine / dimethylsulfoxide / 12 h / 50 °C
View Scheme
参考文献
Nakao, Yoshiaki; Imanaka, Hidekazu; Chen, Jinshui; Yada, Akira; Hiyama, Tamejiro
Journal of Organometallic Chemistry, 2007 , vol. 692, # 1-3 p. 585 - 603
反应条件
1,3-bis-(diphenylphosphino)propane; triethylamine; tris(dibenzylideneacetone)dipalladium (0) in N,N-dimethyl-formamide
T=80°C; Heck coupling; 16 h; Title compound not separated from byproducts.;
参考文献
Rostovtsev, Vsevolod V.; Bryman, Lois M.; Junk, Christopher P.; Harmer, Mark A.; Carcani, Liane G.
Journal of Organic Chemistry, 2008 , vol. 73, # 2 p. 711 - 714
反应条件
palladium diacetate in ethanol; water
T=70°C; Heck arylation; 0.666667 h;
参考文献
Artuso, Emma; Barbero, Margherita; Degani, Iacopo; Dughera, Stefano; Fochi, Rita
Tetrahedron, 2006 , vol. 62, # 13 p. 3146 - 3157
反应条件
sodium hydroxide; 4-hydroacetophenone oxime-derived palladacycle in water
T=120°C; Hiyama reaction; 0.166667 h; microwave irradiation;
参考文献
Alacid, Emilio; Najera, Carmen
Journal of Organic Chemistry, 2008 , vol. 73, # 6 p. 2315 - 2322
反应条件
sodium hydroxide; 4-hydroacetophenone oxime-derived palladacycle in water
T=120°C; Hiyama reaction; 0.166667 h; microwave irradiation;
参考文献
Alacid, Emilio; Najera, Carmen
Journal of Organic Chemistry, 2008 , vol. 73, # 6 p. 2315 - 2322
反应条件
Najera palladacycle I; tetra(n-butyl)ammonium hydroxide; potassium carbonate; [HP(t-Bu)3]BF4 in N,N-dimethyl-formamide
T=130°C; Suzuki-Miyaura alkenylation; 0.333333 h; Microwave irradiation; regioselective reaction;
参考文献
Civicos, Jose F.; Alonso, Diego A.; Najera, Carmen
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 10 p. 1683 - 1687
反应条件
[NiI2(PPh3)]; tri-cyclo-hexyl-phosphine in tetrahydrofuran
T=70°C; Kumada Cross-Coupling; Inert atmosphere; chemoselective reaction;
参考文献
Wu, Ji-Cheng; Gong, Lu-Bing; Xia, Yuanzhi; Song, Ren-Jie; Xie, Ye-Xiang; Li, Jin-Heng
Angewandte Chemie - International Edition, 2012 , vol. 51, # 39 p. 9909 - 9913
反应条件
anhydrous iron chloride; copper (II) acetate monohydrate; iron(II) chloride in dichloromethane; acetic acid
T=20°C; Friedel Crafts type reaction; 26.5 h; Reflux;
参考文献
Dyadchenko, Victor P.; Dyadchenko, Marina A.; Okulov, Vladimir N.; Lemenovskii, Dmitri A.
Journal of Organometallic Chemistry, 2011 , vol. 696, # 2 p. 468 - 472
