4-溴-1H-吡咯-2-羧酸乙酯合成路线 （共 8 条）
反应条件
bromine in tetrachloromethane T=-15°C; 1 h;
参考文献
Bergauer, Markus; Gmeiner, Peter
Synthesis, 2002 , # 2 p. 274 - 278
反应条件
in N,N-dimethyl-formamide T=120°C; 6 h;
参考文献
Handy, Scott T.; Bregman, Howard; Lewis, Jennifer; Zhang, Xiaolei; Zhang, Yanan
Tetrahedron Letters, 2003 , vol. 44, # 3 p. 427 - 430
反应条件
bromine in tetrachloromethane T=0°C;
参考文献
Meyers, Kenneth M.; Mendez-Andino, Jose; Colson, Anny-Odile; Hu, X. Eric; Wos, John A.; Mitchell, Maria C.; Hodge, Karen; Howard, Jeremy; Paris, Jennifer L.; Dowty, Martin E.; Obringer, Cindy M.; Reizes, Ofer
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 3 p. 657 - 661
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=110°C; Suzuki-type coupling; 14 h;
参考文献
Handy, Scott T.; Bregman, Howard; Lewis, Jennifer; Zhang, Xiaolei; Zhang, Yanan
Tetrahedron Letters, 2003 , vol. 44, # 3 p. 427 - 430
反应条件
1: 93 percent / DMAP / acetonitrile / 1 h / 20 °C 2: 70 percent / Na2CO3 / tetrakis(triphenylphosphine)palladium(0) / dimethylformamide; H2O / 15 h / 110 °C View Scheme
参考文献
Handy, Scott T.; Zhang, Yanan; Bregman, Howard
Journal of Organic Chemistry, 2004 , vol. 69, # 7 p. 2362 - 2366
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=110°C; Suzuki-type coupling;
参考文献
Tetrahedron Letters, , vol. 44, # 3 p. 427 - 430
反应条件
C42H58NO3PPdS(2-); potassium acetate; di-tert-butyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine in 1,4-dioxane; water
T=100°C; 1 h; Inert atmosphereSealed tube;
参考文献
Senecal, Todd D.; Shu, Wei; Buchwald, Stephen L.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 38 p. 10035 - 10039
Angew. Chem., 2013 , vol. 125, # 38 p. 10219 - 10223
反应条件
4-(N,N-dimethlyamino)pyridine in acetonitrile
T=20°C; 1 h;
参考文献
Handy, Scott T.; Zhang, Yanan; Bregman, Howard
Journal of Organic Chemistry, 2004 , vol. 69, # 7 p. 2362 - 2366
