1-Alpha-氯-3,5-二-O-对甲苯甲酰基-2-脱氧-D-呋喃核糖合成路线 （共 54 条）
反应条件
trimethylsilyl trifluoromethanesulfonate in 1,2-dichloro-ethane; acetonitrile T=24°C; 3 h;
参考文献
Vorbrueggen, Helmut; Krolikiewicz, Konrad; Bennua, Baerbel
Chemische Berichte, 1981 , vol. 114, # 4 p. 1234 - 1255
反应条件
1: 31.5 percent / (CH3)3SiOSO2CF3 / 1,2-dichloro-ethane; acetonitrile / 3 h / 24 °C 2: xylene / Heating 3: 27 percent / (CH3)3SiOSO2CF3 / acetonitrile; 1,2-dichloro-ethane / 46 h / 24 °C View Scheme
参考文献
Vorbrueggen, Helmut; Krolikiewicz, Konrad; Bennua, Baerbel
Chemische Berichte, 1981 , vol. 114, # 4 p. 1234 - 1255
反应条件
1: 1) sodium hydride (60percent in oil) / 1) acetonitrile, RT, 0.5 h; 2) acetonitrile, RT, 2 h 2: 86 percent / methanol / 1 h / Heating 3: 92 percent / sodium iodide, chlorotrimethylsilane / acetonitrile View Scheme
参考文献
Winkeler, Heinz-Dieter; Seela, Frank
Journal of Organic Chemistry, 1983 , vol. 48, # 18 p. 3119 - 3122
反应条件
1: 61 percent / KOH, tris-<2-(2-methoxyethoxy)ethyl>amine / acetonitrile / 1 h / Ambient temperature 2: 92 percent / methanolic NH3 / 16 h / Ambient temperature 3: 82 percent / AgNO3, pyridine / tetrahydrofuran / 3.5 h / Ambient temperature 4: 85 percent / DMAP / acetonitrile / 28 h / Ambient temperature 5: 90 percent / Bu3SnH, 2,2'-azobis(2-methylpropionitrile) / benzene / 0.33 h / Heating 6: 83 percent / aq. AcOH / 1 h / Ambient temperature 7: 1) hydrazine, 2) Raney Ni / 1) 90 min, reflux, 2) aq. EtOH, reflux, 2 h View Scheme
参考文献
Serafinowski
Synthesis, 1990 , # 9 p. 757 - 760
反应条件
1: 1) sodium hydride (60percent in oil) / 1) acetonitrile, RT, 0.5 h; 2) acetonitrile, RT, 2 h 2: 91 percent / methanolic ammonia / 12 h / Ambient temperature; pressure bottle View Scheme
参考文献
Ramasamy; Imamura; Robins; Revankar
Journal of Heterocyclic Chemistry, 1988 , vol. 25, # 6 p. 1893 - 1898
反应条件
in tetrahydrofuran; acetonitrile T=4°C; 0.5 h;
参考文献
Shinozuka, Kazuo; Morita, Tsutomu; Hirota, Yoshiki; Sawai, Hiroaki
Chemistry Letters, 1991 , # 11 p. 1941 - 1944
反应条件
in chloroform-d1 48 h;
参考文献
Rolland, Valerie; Kotera, Mitsuharu; Lhomme, Jean
Synthetic Communications, 1997 , vol. 27, # 20 p. 3505 - 3511
反应条件
1: 1) NaH / 1) MeCN, 60 deg C, 10 min; 2) 60 deg C, 10 min 2: 26 percent / NH3 / methanol / 48 h / 70 - 75 °C View Scheme
参考文献
Kazimierczuk, Zygmunt; Seela, Frank
Liebigs Annalen der Chemie, 1990 , # 7 p. 647 - 651
反应条件
sodium hydride 1) acetonitrile, RT, 30 min; 2) acetonitrile, 20 h; Yield given. Multistep reaction;
参考文献
Hanna; Ramasamy; Robins; Revankar
Journal of Heterocyclic Chemistry, 1988 , vol. 25, # 6 p. 1899 - 1903
反应条件
1: pyridine / CH2Cl2 / 1 h / Ambient temperature 2: 55 percent / Pd(Ph3P)4 / toluene / 22 h / Heating 3: 70 percent / 0.1 M NaOMe View Scheme
参考文献
Wigerinck, P.; Pannecouque, C.; Snoeck, R.; Claes, P.; Clercq, E. De; Herdewijn, P.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2383 - 2389
