反应条件
1: 1) lithium diisopropyl amide / 1) THF, a) -78 deg C, 100 min, b) 10 deg C, 60 min, 2) 40 min 2: KOH; ethanol / 4 h 3: nBu4NCN / 8 h / 75 °C 4: 45 percent / ozone, sodium bicarbonate / ethyl acetate / 8 h / 0 °C 5: 92 percent / NaBH4 / ethanol / 1.5 h / Ambient temperature 6: conc. HCl / CH2Cl2 / 31 h 7: AIBN, tri-n-butyltin hydride / toluene / 2 h / Heating 8: 93 percent / ozone / ethyl acetate / 0.5 h / -78 °C 9: SOCl2 / methanol / 2 h 10: 99 percent / NaBH4, CeCl3*7H2O / methanol / 0.08 h 11: 92 percent / PBr3 / petroleum ether / 1 h / 0 °C 12: 1) NaI, 2) NaBH4 / 1) DMSO, r.t., 15 min, 2) MeOH, 1.5 h 13: 90 percent / DIBAL-H / benzene; toluene / 2 h / 0 °C View Scheme
参考文献
Kutney, James P.; Gunning, Philip J.; Clewley, Robin G.; Somerville, John; Rettig, Steven J.
Canadian Journal of Chemistry, 1992 , vol. 70, # 7 p. 2094 - 2114
