5-溴-4-甲氧基-6-甲基嘧啶合成路线 （共 3 条）
反应条件
in methanol
T=20°C; 1 h;
参考文献
INCYTE CORPORATION
Patent: WO2005/105814 A1, 2005 ;
Location in patent: Page/Page column 67-68 ;
WO 2005/105814 A1
反应条件
sodium methylate
T=20°C; 3 h; chemoselective reaction;
参考文献
Wang, Zhihan; Chi, Yushi; Harris, Anthony R.; Gray, David; Davoren, Jennifer E.
Synthesis, 2011 , # 10 art. no. M25011SS, p. 1529 - 1531
反应条件
1: N-bromosuccinmide / acetonitrile / 1 h / 20 °C / Inert atmosphere
2: trichlorophosphate / 3 h / 20 °C / Inert atmosphere; Reflux
3: sodium methylate / 3 h / 20 °C
View Scheme
参考文献
Wang, Zhihan; Chi, Yushi; Harris, Anthony R.; Gray, David; Davoren, Jennifer E.
Synthesis, 2011 , # 10 art. no. M25011SS, p. 1529 - 1531
