6-氯-4,5-嘧啶二胺合成路线 （共 15 条）
反应条件
ammonia in water T=100°C; 46 h;
参考文献
ASTEX THERAPEUTICS LIMITED; THE INSTITUTE OF CANCER RESEARCH:ROYAL CANCER HOSPITAL; CANCER RESEARCH TECHNOLOGY LIMITED; ASTRAZENECA AB
Patent: WO2007/125325 A1, 2007 ;
Location in patent: Page/Page column 92-93 ;
WO 2007/125325 A1
反应条件
tin(ll) chloride in ethanol 1 h; Heating;
参考文献
Baraldi, Pier Giovanni; Broceta, Asier Unciti; Infantas, Maria Jose Pineda De Las; Mochun, Juan Jose Diaz; Espinosa, Antonio; Romagnoli, Romeo
Tetrahedron, 2002 , vol. 58, # 38 p. 7607 - 7611
反应条件
N,N-dimethyl-aniline; trichlorophosphate 4 h; Heating / reflux;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/13141 A1, 2004 ;
Location in patent: Page 134 ;
WO 2004/013141 A1
反应条件
sodium hydroxide in water T=50.1°C; other temperatures; alkalyne hydrolysis of 6-substituted 9-(1-ethoxyethyl)purines, effect of substituent, formation of intermediates; Product distributionRate constant;
参考文献
Loennberg, Harri; Lehikoinen, Pertti; Neuvonen, Kari
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1982 , vol. 36, # 10 p. 707 - 712
参考文献
Albert et al.
Journal of the Chemical Society, 1952 , p. 4219,4220
反应条件
sodium hydride T=95°C; 24 h;
参考文献
Baraldi, Pier Giovanni; Broceta, Asier Unciti; Infantas, Maria Jose Pineda De Las; Mochun, Juan Jose Diaz; Espinosa, Antonio; Romagnoli, Romeo
Tetrahedron, 2002 , vol. 58, # 38 p. 7607 - 7611
参考文献
Bendich et al.
Journal of the American Chemical Society, 1954 , vol. 76, p. 6073,6076
参考文献
Bendich et al.
Journal of the American Chemical Society, 1954 , vol. 76, p. 6073,6076
反应条件
palladium on activated charcoal; water Hydrogenation;
参考文献
Bendich et al.
Journal of the American Chemical Society, 1954 , vol. 76, p. 6073,6076
反应条件
sulfur in N,N-dimethyl-formamide T=90 - 100°C;
参考文献
Tandel, Sagun; Bliznets, Igor; Ebinger, Katalin; Ma, You-An; Bhumralkar, Dilip; Thiruvazhi, Mohan
Tetrahedron Letters, 2004 , vol. 45, # 11 p. 2321 - 2322
