4,6-二氯-5-甲基嘧啶合成路线 （共 5 条）
反应条件
N,N-dimethyl-formamide; trichlorophosphate 3 h; Heating / reflux;
参考文献
Gharbaoui, Tawfik; Fritch, John R.; Krishnan, Ashwin M.; Throop, Beverly Wolgast; Kato, Naomi S.
Patent: US2006/155129 A1, 2006 ;
Location in patent: Page/Page column 14 ;
US 20060155129 A1
反应条件
caesium carbonate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide; toluene T=140°C; 1 h; Irradiation;
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/3997 A1, 2009 ;
Location in patent: Page/Page column 20-21 ;
WO 2009/003997 A1
反应条件
methanol; palladium on activated charcoal; magnesium oxide Hydrogenation;
参考文献
Wiley; Slaymaker
Journal of the American Chemical Society, 1957 , vol. 79, p. 2233,2234
反应条件
1: in isobutyramide
T=-8°C; 1 h;
2: With potassium carbonate in isobutyramide
T=-7.2 - 20°C; 5 h;
参考文献
Arena Pharmaceuticals, Inc.
Patent: EP1931654 B1, 2009 ;
Location in patent: Page/Page column 17 ;
反应条件
in methanol
T=0 - 50°C; 20.3333 h;
参考文献
ARRAY BIOPHARMA INC.; GENENTECH, INC.
Patent: WO2007/146824 A2, 2007 ;
Location in patent: Page/Page column 115 ;
WO 2007/146824 A2
